Lessons in aging from Myc knockout mouse models
EV Prochownik, H Wang - Frontiers in Cell and Developmental …, 2023 - frontiersin.org
Despite MYC being among the most intensively studied oncogenes, its role in normal
development has not been determined as Myc−/− mice do not survival beyond mid …
development has not been determined as Myc−/− mice do not survival beyond mid …
[HTML][HTML] Mechanistic drivers of chromatin organization into compartments
HL Harris, MJ Rowley - Current Opinion in Genetics & Development, 2024 - Elsevier
Highlights•Recent work indicates that chromatin compartments can finely segregate
genomic intervals that are 1–2 kb in size.•Evidence both supports and refutes several …
genomic intervals that are 1–2 kb in size.•Evidence both supports and refutes several …
Chromosome compartmentalization: causes, changes, consequences, and conundrums
The spatial segregation of the genome into compartments is a major feature of 3D genome
organization. New data on mammalian chromosome organization across different conditions …
organization. New data on mammalian chromosome organization across different conditions …
Premature aging in genetic diseases: what conclusions can be drawn for physiological aging
F Milosic, M Hengstschläger, S Osmanagic-Myers - Frontiers in Aging, 2024 - frontiersin.org
According to current views the major hallmarks of physiological aging may be subdivided
into three categories, primary causes of cellular damage (genomic instability, telomere …
into three categories, primary causes of cellular damage (genomic instability, telomere …
Transcription and 3D Chromatin Organization Interplay at Sub-Kilobase Scale
H Harris - 2024 - digitalcommons.unmc.edu
Nuclear compartments are prominent features of 3D chromatin organization, but sequencing
depth limitations have impeded investigation at ultra fine-scale. CTCF loops are generally …
depth limitations have impeded investigation at ultra fine-scale. CTCF loops are generally …