The importance of the ratio of omega-6/omega-3 essential fatty acids

AP Simopoulos - Biomedicine & pharmacotherapy, 2002 - Elsevier
Several sources of information suggest that human beings evolved on a diet with a ratio of
omega-6 to omega-3 essential fatty acids (EFA) of∼ 1 whereas in Western diets the ratio is …

Omega-3 fatty acids in health and disease and in growth and development

AP Simopoulos - The American journal of clinical nutrition, 1991 - Elsevier
Several sources of information suggest that man evolved on a diet with a ratio of ω6 to ω3
fatty acids of∼ 1 whereas today this ratio is∼ 10: 1 to 20–25: 1, indicating that Western diets …

[HTML][HTML] Importance of n− 3 fatty acids in health and disease

WE Connor - The American journal of clinical nutrition, 2000 - Elsevier
In the past 2 decades, views about dietary n− 3 fatty acids have moved from speculation
about their functions to solid evidence that they are not only essential nutrients but also may …

Dietary n-3 polyunsaturated fatty acids and amelioration of cardiovascular disease: possible mechanisms

JE Kinsella, B Lokesh, RA Stone - The American journal of clinical nutrition, 1990 - Elsevier
Consumption of n-3 polyunsaturated fatty acids (n-3 PUFAs) is associated with a reduced
incidence of coronary arterial diseases. Dietary n-3 PUFAs act via several mechanisms …

The effect of dietary Ω-3 fatty acids on coronary atherosclerosis: a randomized, double-blind, placebo-controlled trial

C Von Schacky, P Angerer, W Kothny… - Annals of internal …, 1999 - acpjournals.org
Background: Epidemiologic studies, studies of mechanisms of action, and many animal
studies indicate that dietary intake of ω-3 fatty acids has antiatherosclerotic potential. Few …

The omega-3 fatty acid docosahexaenoate reduces cytokine-induced expression of proatherogenic and proinflammatory proteins in human endothelial cells.

R De Caterina, MI Cybulsky, SK Clinton… - … and thrombosis: a …, 1994 - Am Heart Assoc
The mechanisms by which dietary fatty acids can modulate atherogenesis and inflammation
are poorly understood. Induction in endothelial cells of adhesion molecules for circulating …

Intake of fish and n3 fatty acids and risk of coronary heart disease among Japanese: the Japan Public Health Center-Based (JPHC) Study Cohort I

H Iso, M Kobayashi, J Ishihara, S Sasaki, K Okada… - Circulation, 2006 - Am Heart Assoc
Background—Once-or twice-weekly consumption of fish (or a small amount of fish intake)
reduces the risk of coronary heart disease and sudden cardiac death in Western countries. It …

Importance of the ratio of omega-6/omega-3 essential fatty acids: evolutionary aspects

AP Simopoulos - Omega-6/omega-3 essential fatty acid ratio: The …, 2003 - karger.com
The interaction of genetics and environment, nature, and nurture is the foundation for all
health and disease. In the last two decades, using the techniques of molecular biology, it …

Omega-3 fatty acids and inflammation

TA Mori, LJ Beilin - Current atherosclerosis reports, 2004 - Springer
Abstract Dietary omega-3 (n-3) fatty acids have a variety of anti-inflammatory and immune-
modulating effects that may be of relevance to atherosclerosis and its clinical manifestations …

Intake of fish and omega-3 fatty acids and risk of stroke in women

H Iso, KM Rexrode, MJ Stampfer, JAE Manson… - Jama, 2001 - jamanetwork.com
ContextSome prospective studies have shown an inverse association between fish intake
and risk of stroke, but none has examined the relationship of fish and omega-3 …