The MRE11–RAD50–NBS1 complex conducts the orchestration of damage signaling and outcomes to stress in DNA replication and repair
Genomic instability in disease and its fidelity in health depend on the DNA damage
response (DDR), regulated in part from the complex of meiotic recombination 11 homolog 1 …
response (DDR), regulated in part from the complex of meiotic recombination 11 homolog 1 …
HBV cccDNA: viral persistence reservoir and key obstacle for a cure of chronic hepatitis B
M Nassal - Gut, 2015 - gut.bmj.com
At least 250 million people worldwide are chronically infected with HBV, a small
hepatotropic DNA virus that replicates through reverse transcription. Chronic infection …
hepatotropic DNA virus that replicates through reverse transcription. Chronic infection …
DNA double-strand-break repair in higher eukaryotes and its role in genomic instability and cancer: Cell cycle and proliferation-dependent regulation
E Mladenov, S Magin, A Soni, G Iliakis - Seminars in cancer biology, 2016 - Elsevier
Eukaryotic cells respond to DNA damage by activating a comprehensive network of
biochemical pathways that enable damage recognition and initiate responses leading to …
biochemical pathways that enable damage recognition and initiate responses leading to …
Eukaryotic DNA replication fork
PMJ Burgers, TA Kunkel - Annual review of biochemistry, 2017 - annualreviews.org
This review focuses on the biogenesis and composition of the eukaryotic DNA replication
fork, with an emphasis on the enzymes that synthesize DNA and repair discontinuities on the …
fork, with an emphasis on the enzymes that synthesize DNA and repair discontinuities on the …
[HTML][HTML] Emerging critical roles of Fe–S clusters in DNA replication and repair
Fe–S clusters are partners in the origin of life that predate cells, acetyl-CoA metabolism,
DNA, and the RNA world. The double helix solved the mystery of DNA replication by base …
DNA, and the RNA world. The double helix solved the mystery of DNA replication by base …
Involvement of the host DNA-repair enzyme TDP2 in formation of the covalently closed circular DNA persistence reservoir of hepatitis B viruses
C Königer, I Wingert, M Marsmann… - Proceedings of the …, 2014 - National Acad Sciences
Hepatitis B virus (HBV), the causative agent of chronic hepatitis B and prototypic
hepadnavirus, is a small DNA virus that replicates by protein-primed reverse transcription …
hepadnavirus, is a small DNA virus that replicates by protein-primed reverse transcription …
APE1: A skilled nucleic acid surgeon
AM Whitaker, BD Freudenthal - DNA repair, 2018 - Elsevier
Before a deleterious DNA lesion can be replaced with its undamaged counterpart, the lesion
must first be removed from the genome. This process of removing and replacing DNA …
must first be removed from the genome. This process of removing and replacing DNA …
Control of structure-specific endonucleases to maintain genome stability
PM Dehé, PHL Gaillard - Nature reviews Molecular cell biology, 2017 - nature.com
Abstract Structure-specific endonucleases (SSEs) have key roles in DNA replication,
recombination and repair, and emerging roles in transcription. These enzymes have …
recombination and repair, and emerging roles in transcription. These enzymes have …
Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease
JL Grieves, JM Fye, S Harvey… - Proceedings of the …, 2015 - National Acad Sciences
The TREX1 gene encodes a potent DNA exonuclease, and mutations in TREX1 cause a
spectrum of lupus-like autoimmune diseases. Most lupus patients develop autoantibodies to …
spectrum of lupus-like autoimmune diseases. Most lupus patients develop autoantibodies to …
A scanning-to-incision switch in TFIIH-XPG induced by DNA damage licenses nucleotide excision repair
Nucleotide excision repair (NER) is critical for removing bulky DNA base lesions and
avoiding diseases. NER couples lesion recognition by XPC to strand separation by XPB and …
avoiding diseases. NER couples lesion recognition by XPC to strand separation by XPB and …