Circulating tumor cells: approaches to isolation and characterization

M Yu, S Stott, M Toner, S Maheswaran… - Journal of Cell …, 2011 - rupress.org
Circulating tumor cells (CTCs) shed from primary and metastatic cancers are admixed with
blood components and are thus rare, making their isolation and characterization a major …

[HTML][HTML] Detecting circulating tumor cells: current challenges and new trends

B Hong, Y Zu - Theranostics, 2013 - ncbi.nlm.nih.gov
Circulating tumor cells (CTCs) in the blood stream play a critical role in establishing
metastases. The clinical value of CTCs as a biomarker for early cancer detection, diagnosis …

Circulating tumor cells predict survival in early average-to-high risk breast cancer patients

B Rack, C Schindlbeck, J Jückstock… - Journal of the …, 2014 - academic.oup.com
Abstract Background Circulating tumor cells (CTCs) have been shown to predict reduced
survival outcomes in metastatic breast cancer. Methods CTCs were analyzed in 2026 …

Pooled analysis of the prognostic relevance of circulating tumor cells in primary breast cancer

WJ Janni, B Rack, LWMM Terstappen, JY Pierga… - Clinical Cancer …, 2016 - AACR
Purpose: Although unequivocal evidence has shown the prognostic relevance of circulating
tumor cells (CTC) in the peripheral blood of patients with metastatic breast cancer, less …

Meta-analysis of the prognostic value of circulating tumor cells in breast cancer

L Zhang, S Riethdorf, G Wu, T Wang, K Yang… - Clinical cancer …, 2012 - AACR
Purpose: The prognostic value of circulating tumor cells (CTC) detected in breast cancer
patients is currently under debate. Different time points of blood collections and various CTC …

Human breast cancer metastases to the brain display GABAergic properties in the neural niche

J Neman, J Termini, S Wilczynski… - Proceedings of the …, 2014 - National Acad Sciences
Dispersion of tumors throughout the body is a neoplastic process responsible for the vast
majority of deaths from cancer. Despite disseminating to distant organs as malignant scouts …

Biomarkers for the clinical management of breast cancer: international perspective

N Patani, LA Martin, M Dowsett - International journal of cancer, 2013 - Wiley Online Library
The higher incidence of breast cancer in developed countries has been tempered by
reductions in mortality, largely attributable to mammographic screening programmes and …

Epithelial-to-mesenchymal transitions and circulating tumor cells

A Bonnomet, A Brysse, A Tachsidis, M Waltham… - Journal of mammary …, 2010 - Springer
Epithelial-to-mesenchymal transition (EMT) phenomena endow epithelial cells with
enhanced migratory and invasive potential, and as such, have been implicated in many …

Circulating tumor cells: advances in detection methods, biological issues, and clinical relevance

YF Sun, XR Yang, J Zhou, SJ Qiu, J Fan… - Journal of cancer research …, 2011 - Springer
Abstract Background Circulating tumor cells (CTCs) have long been considered a reflection
of tumor aggressiveness. Hematogenous spreading of CTCs from a primary tumor is a …

Probing circulating tumor cells in microfluidics

P Li, ZS Stratton, M Dao, J Ritz, TJ Huang - Lab on a Chip, 2013 - pubs.rsc.org
Circulating tumor cells (CTCs) are important targets for study as we strive to better
understand, diagnose, and treat cancers. However, CTCs are found in blood at extremely …