This article comprehensively reviews the lateral fluid percussion (LFP) model of traumatic
brain injury (TBI) in small animal species with particular emphasis on its validity, clinical …

BACKGROUND: Neuronal cell death after general anesthesia has recently been
documented in several immature animal models. Worldwide, volatile anesthetics are used in …

Translational stroke research is a challenging task that needs long term team work of the
stroke research community. Highly reproducible stroke models with excellent outcome …

Ischemic neuronal injury is characterized by early death mediated by excitotoxicity and by
delayed death caused by apoptosis. Current evidence indicates that volatile agents …

Penumbra is the viable tissue around the irreversibly damaged ischemic core. The purpose
of acute stroke treatment is to salvage penumbral tissue and to improve brain function …

Rodent models of focal cerebral ischemia are essential tools in experimental stroke
research. They have added tremendously to our understanding of injury mechanisms in …

The aim of this study was to investigate whether propofol could provide postconditioning to
ischemic brain injury and the role of phosphoinositide-3-kinase/Akt (PI3K/Akt) pathway in …

Isoflurane is commonly used in experimental traumatic brain injury (TBI), both before and
early after injury, yet it is rarely used clinically. Narcotics and benzodiazepines are frequently …

Background Propofol has not been studied directly in animals subject to cerebral ischemia
in the conscious state. Strokes are usually induced in animals while they are anesthetized …

We have investigated the effects of isoflurane and desflurane on neurological outcome in a
rat model of incomplete cerebral ischaemia. We studied 40 non-fasted male Sprague …