Microbes transiently differentiate into distinct, specialized cell types to generate functional
diversity and cope with changing environmental conditions. Though alternate programs …

How transcriptional bursting relates to gene regulation is a central question that has
persisted for more than a decade. Here, we measure nascent transcriptional activity in early …

Both engineering and evolution are constrained by trade-offs between efficiency and
robustness, but theory that formalizes this fact is limited. For a simple two-state model of …

Recent experimental results indicate that, in single Escherichia coli cells, the fluctuations in
mRNA level are uncorrelated with those of protein. However, a basic two-stage model for …

This book is, of course, about stochastic chemical kinetics. Chemical kinetics is a prototype
of nonlinear science, since the rate of reaction is generally a nonlinear function of the …

Feedback loops are ubiquitous features of biological networks and can produce significant
phenotypic heterogeneity, including a bimodal distribution of gene expression across an …

A hybrid CMOS/thin-film microsystem for fluorescence contact imaging is presented. The
microsystem integrates a high-performance optical interference filter and a 128× 128 pixel …

In this Letter, taking into account the structure variations at discrete time instances during the
process of gene regulation, a hybrid genetic regulatory networks model based on Markov …

Gene expression at the single-cell level incorporates reaction mechanisms which are
intrinsically stochastic as they involve molecular species present at low copy numbers. The …

Biochemical processes are inherently stochastic, creating molecular fluctuations in
otherwise identical cells. Such “noise” is widespread but has proven difficult to analyze …