[HTML][HTML] A review and perspective on hybrid modelling methodologies

AM Schweidtmann, D Zhang, M von Stosch - Digital Chemical Engineering, 2023 - Elsevier
The term hybrid modeling refers to the combination of parametric models (typically derived
from knowledge about the system) and nonparametric models (typically deduced from data) …

From Shallow to Deep Bioprocess Hybrid Modeling: Advances and Future Perspectives

R Agharafeie, JRC Ramos, JM Mendes, R Oliveira - Fermentation, 2023 - mdpi.com
Deep learning is emerging in many industrial sectors in hand with big data analytics to
streamline production. In the biomanufacturing sector, big data infrastructure is lagging …

[HTML][HTML] Hybrid Modeling for On-Line Fermentation Optimization and Scale-Up: A Review

M Albino, CL Gargalo, G Nadal-Rey, MO Albæk… - Processes, 2024 - mdpi.com
Modeling is a crucial tool in the biomanufacturing industry, namely in fermentation
processes. This work discusses both mechanistic and data-driven models, each with unique …

Hybrid Modeling of Fed-Batch Cell Culture Using Physics-Informed Neural Network

S Yang, W Fahey, B Truccollo, J Browning… - Industrial & …, 2024 - ACS Publications
Fed-batch cell culture is widely used in the biopharmaceutical industry to manufacture life-
saving therapeutics. Biopharmaceutical manufacturing processes can be variable due to the …

Data-driven inference of bioprocess models: A low-rank matrix approximation approach

GA Pimentel, L Dewasme, AV Wouwer - Journal of Process Control, 2024 - Elsevier
Following the recent advent of Process Analytical Technologies, dataset production has
undergone significant leverage. In this new abundance of data, isolating meaningful …

[PDF][PDF] Data-driven inference of bioprocess models: A low-rank matrix approximation approach

L Dewasme - Journal of Process Control, 2024 - orbi.umons.ac.be
Following the recent advent of Process Analytical Technologies, dataset production has
undergone significant leverage. In this new abundance of data, isolating meaningful …

[PDF][PDF] Digital Chemical Engineering

The term hybrid modeling refers to the combination of parametric models (typically derived
from knowledge about the system) and nonparametric models (typically deduced from data) …