Autism Spectrum Disorder (ASD) is one of the most prevalent neurodevelopmental
disorders, affecting an estimated 1 in 59 children. ASD is highly genetically heterogeneous …

Human pluripotent stem cells have emerged as a promising in vitro model system for
studying the brain. Two-dimensional and three-dimensional cell culture paradigms have …

Abstract Evaluation of expression profile in autism spectrum disorder (ASD) patients is an
important approach to understand possible similar functional consequences that may …

Autism spectrum disorder (ASD) is a complex neurodevelopmental monogenic disorder with
a strong genetic influence. Idiopathic autism could be defined as a type of autism that does …

Potentially pathogenic alterations have been identified in individuals with autism spectrum
disorders (ASDs) within a variety of key neurodevelopment genes. While this hints at a …

During development, pyramidal neurons undergo dynamic regulation of AMPA receptor
(AMPAR) subunit composition and density to help drive synaptic plasticity and maturation …

Despite decades of study, elucidation of the underlying etiology of complex developmental
disorders such as autism spectrum disorder (ASD), schizophrenia (SCZ), intellectual …

Human induced pluripotent stem cells (hiPSC) provide an attractive tool to study disease
mechanisms of neurodevelopmental disorders such as schizophrenia. A pertinent problem …

Background In recent years, several hundred autism spectrum disorder (ASD) implicated
genes have been discovered impacting a wide range of molecular pathways. However, the …

Across disciplines, there is great anticipation that evolving cell therapies may finally provide
a therapeutic option for conditions in dire need. These conditions are typically complex and …