The spatiotemporal control of gene expression is dependent on the activity of cis-acting
regulatory sequences, called enhancers, which regulate target genes over variable genomic …

The human genome is organized into multiple structural layers, ranging from chromosome
territories to progressively smaller substructures, such as topologically associating domains …

Molecular mechanistic biology has ushered us into the world of life's building blocks,
revealing their interactions in macromolecular complexes and inspiring strategies for …

Liquid droplets formed inside the cell by liquid–liquid phase separation maintain membrane-
less condensates/bodies (or compartments). These droplets are important for concentrating …

It is essential for cells to control which genes are transcribed into RNA. In eukaryotes, two
major control points are recruitment of RNA polymerase II (Pol II) into a paused state, and …

Malate-aspartate shuttle (MAS) is essential for maintaining glycolysis and energy
metabolism in tumors, while its regulatory mechanisms in neuroblastoma (NB), the …

Background Biomolecular condensates have been implicated in multiple cellular processes.
However, the global role played by condensates in 3D chromatin organization remains …

Rationale: Sepsis is a potentially life-threatening condition caused by the body's response to
a severe infection. Although the identification of multiple pathways involved in inflammation …

Chromatin domains and loops are important elements of chromatin structure and dynamics,
but much remains to be learned about their exact biological role and nature. Topological …

Self-nonself discrimination is vital for the immune system to mount responses against
pathogens while maintaining tolerance toward the host and innocuous commensals during …