Synergy and antagonism in natural product extracts: when 1+ 1 does not equal 2

LK Caesar, NB Cech - Natural product reports, 2019 - pubs.rsc.org
Covering: 2000 to 2019 According to a 2012 survey from the Centers for Disease Control
and Prevention, approximately 18% of the US population uses natural products (including …

Interactions between medical plant-derived bioactive compounds: focus on antimicrobial combination effects

N Vaou, E Stavropoulou, C Voidarou, Z Tsakris… - Antibiotics, 2022 - mdpi.com
It is accepted that the medicinal use of complex mixtures of plant-derived bioactive
compounds is more effective than purified bioactive compounds due to beneficial …

Analysis of mulberry leaf components in the treatment of diabetes using network pharmacology

Q Ge, L Chen, M Tang, S Zhang, L Liu, L Gao… - European Journal of …, 2018 - Elsevier
Mulberry leaves are one of the most commonly used medicinal and herbaceous traditional
Chinese medicines that are currently considered for the treatment of diabetes mellitus and …

Computer-aided drug discovery and design: recent advances and future prospects

A Talevi - Computational Drug Discovery and Design, 2023 - Springer
Computer-aided drug discovery and design involve the use of information technologies to
identify and develop, on a rational ground, chemical compounds that align a set of desired …

Revealing the potential mechanism of Astragalus membranaceus improving prognosis of hepatocellular carcinoma by combining transcriptomics and network …

Z Liu, H Ma, Z Lai - BMC complementary medicine and therapies, 2021 - Springer
Background Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related
death. Traditional Chinese medicine (TCM) has special advantages in relieving HCC, while …

Integrated serum pharmacochemistry, metabolomics, and network pharmacology to reveal the material basis and mechanism of Danggui Shaoyao San in the …

H Xiong, N Li, L Zhao, Z Li, Y Yu, X Cui, Q Liu… - Frontiers in …, 2022 - frontiersin.org
Danggui Shaoyao San (DSS), a well-known formula, has been successfully applied in
treating primary dysmenorrhea (PD) in China. However, its material basis and mechanism …

[HTML][HTML] Network pharmacology-based identification of the key mechanism of Qinghuo Rougan Formula acting on uveitis

C Jing, Z Sun, X Xie, X Zhang, S Wu, K Guo… - Biomedicine & …, 2019 - Elsevier
Abstract Background Qinghuo Rougan Formula (QHRGF) is a traditional Chinese medicine
(TCM) that has been widely apllied to treat uveitis for several decades. However, the …

Pharmacoinformatics Analysis Reveals Flavonoids and Diterpenoids from Andrographis paniculata and Thespesia populnea to Target Hepatocellular Carcinoma …

VS Patil, DR Harish, U Vetrivel, SH Deshpande… - Applied Sciences, 2022 - mdpi.com
Herbs are widely utilized in the Western Ghats region of India to treat liver diseases and viral-
like infections. However, such practices lack scientific evidence at the molecular level and …

[HTML][HTML] Network pharmacology based anti-diabetic attributes of bioactive compounds from Ocimum gratissimum L. through computational approach

RY Halayal, ZK Bagewadi, RB Maliger… - Saudi Journal of …, 2023 - Elsevier
The present research was framed to determine the key compounds present in the plant
Ocimum gratissimum L. targeting protein molecules of Diabetes Mellitus (DM) by employing …

Discovery of novel ligands for TNF-α and TNF receptor-1 through structure-based virtual screening and biological assay

S Chen, Z Feng, Y Wang, S Ma, Z Hu… - Journal of chemical …, 2017 - ACS Publications
Tumor necrosis factor α (TNF-α) is overexpressed in various diseases, and it has been a
validated therapeutic target for autoimmune diseases. All therapeutics currently used to …