Motor neurons (MNs) are neuronal cells located in the central nervous system (CNS)
controlling a variety of downstream targets. This function infers the existence of MN subtypes …

Understanding how thousands of different neuronal types are generated in the CNS
constitutes a major challenge for developmental neurobiologists and is a prerequisite before …

The spinal cord contains neuronal circuits termed Central Pattern Generators (CPGs) that
coordinate rhythmic motor activities. CPG circuits consist of motor neurons and multiple …

Glioblastoma (GBM) is the most common and deadly malignant brain cancer, with a median
survival of< 2 years. GBM displays a cellular complexity that includes brain tumour-initiating …

HMX3 is a homeodomain protein with essential roles in CNS and ear development.
Homeodomains are DNA-binding domains and hence homeodomain-containing proteins …

We have assembled a network of cell-fate determining transcription factors that play a key
role in the specification of the ventral neuronal subtypes of the spinal cord on the basis of …

Unravelling how neurons are guided during vertebrate embryonic development has wide
implications for understanding the assembly of the nervous system. During embryogenesis …

Abstract The Groucho/transducin-like Enhancer of split 1 (Gro/TLE1): Hes1 transcriptional
repression complex acts in cerebral cortical neural progenitor cells to inhibit neuronal …

Background: How tissue patterns form in development and regeneration is a fundamental
issue remaining to be fully understood. The integument often forms repetitive units in space …

Loss of insulin-producing β cell numbers and/or function are the defining characteristics of
diabetes. Research on the cellular mechanisms that lead to these diseases is focused on …