Nociceptors, ie sensory neurons tuned to detect noxious stimuli, are found in numerous
phyla of the Animalia kingdom and are often polymodal, responding to a variety of stimuli, eg …

The DEG/ENaC family of ion channels was defined based on the sequence similarity
between degenerins (DEG) from the nematode Caenorhabditis elegans and subunits of the …

Ion channels of the degenerin (DEG)/epithelial Na+ channel (ENaC) family serve diverse
functions ranging from mechanosensation over Na+ reabsorption to H+ sensing and …

Acid-sensing ion channels (ASICs) are proton-gated cation channels that contribute to
neurotransmission, as well as initiation of pain and neuronal death following ischemic …

Ion channels of the DEG/ENaC family share a similar structure but serve strikingly diverse
biological functions, such as Na+ reabsorption, mechanosensing, proton-sensing …

Extracellular pH changes may constitute significant signals for neuronal communication.
During synaptic transmission, changes in pH in the synaptic cleft take place. Its role in the …

The only known peptide-gated ion channels—FaNaCs/WaNaCs and HyNaCs—belong to
different clades of the DEG/ENaC family. FaNaCs are activated by the short neuropeptide …

Prolonged acidosis, as it occurs during ischemic stroke, induces neuronal death via acid-
sensing ion channel 1a (ASIC1a). Concomitantly, it desensitizes ASIC1a, highlighting the …

Acid-sensitive ion channels belonging to the degenerin/epithelial sodium channel
(DEG/ENaC) family activate in response to extracellular protons and are considered unique …

Acid-sensing ion channel (ASIC) channels belong to the family of ligand-gated ion channels
known as acid-sensing (proton-gated) ion channels. Only a few activators of ASICs are …