The neurodegenerative diseases, Alzheimer's disease (AD) and Parkinson's disease (PD),
are age-related disorders characterized by the deposition of abnormal forms of specific …

Neurons are critically dependent on mitochondrial integrity based on specific morphological,
biochemical, and physiological features. They are characterized by high rates of metabolic …

Neurodegenerative diseases selectively target subpopulations of neurons, leading to the
progressive failure of defined brain systems, but the basis of such selective neuronal …

Mitochondrial electron transport generates the ATP that is essential for the excitability and
survival of neurons, and the protein phosphorylation reactions that mediate synaptic …

Mitochondria are highly dynamic organelles which fulfill a plethora of functions. In addition to
their prominent role in energy metabolism, mitochondria are intimately involved in various …

Parkin, an E3 ubiquitin ligase and a Parkinson's disease (PD) related gene, translocates to
impaired mitochondria and drives their elimination via autophagy, a process known as …

Melatonin is mainly produced in the mammalian pineal gland during the dark phase. Its
secretion from the pineal gland has been classically associated with circadian and circanual …

Parkinson's disease (PD) is the second most common neurodegenerative disorder mostly
affecting the aging population over sixty. Cardinal symptoms including, tremors, muscle …

Loss-of-function mutations in the parkin gene (PARK2) and PINK1 gene (PARK6) are
associated with autosomal recessive parkinsonism. PINK1 deficiency was recently linked to …

Parkinson's disease (PD), the most frequent movement disorder, is caused by the
progressive loss of the dopamine neurons within the substantia nigra pars compacta (SNc) …