Peptide-based supramolecular systems chemistry seeks to mimic the ability of life forms to
use conserved sets of building blocks and chemical reactions to achieve a bewildering array …

Many biomolecular condensates appear to form via spontaneous or driven processes that
have the hallmarks of intracellular phase transitions. This suggests that a common …

The mechanisms underlying ribonucleoprotein (RNP) granule assembly, including the basis
for establishing and maintaining RNP granules with distinct composition, are unknown. One …

INTRODUCTION Stress granules are dynamic structures composed of RNA and protein that
arise in the cytoplasm in response to a variety of stressors. These structures form via liquid …

Biological phase separation is known to be important for cellular organization, which has
recently been extended to a new class of biomolecules that form liquid-like droplets …

Malignant transformation is characterized by dysregulation of diverse cellular processes that
have been the subject of detailed genetic, biochemical, and structural studies, but only …

Recognition of the natural abundance and functional importance of intrinsically disordered
proteins (IDPs), and protein hybrids that contain both intrinsically disordered protein regions …

It is unclear how disease mutations impact intrinsically disordered protein regions (IDRs),
which lack a stable folded structure. These mutations, while prevalent in disease, are …

Motions in biomolecules are critical for biochemical reactions. In cells, many biochemical
reactions are executed inside of biomolecular condensates formed by ultradynamic …

Liquid–liquid phase separation plays an important role in cellular organization. Many
subcellular condensed bodies are hierarchically organized into multiple coexisting domains …