The transcription factors of the p53 family comprise three proteins: p53, p63, and p73. As
extensively described, the p53 family, a widely known cell regulator, adjusts a series of …

Epithelial tissue homeostasis is closely associated with the self-renewal and differentiation
behaviors of epithelial stem cells (ESCs). p63, a well-known marker of ESCs, is an …

Salivary glands consist of several epithelial cell types of distinct lineages and functional
characteristics that are established by directed differentiation programs of resident stem and …

Purpose: We carried out a histological characterization analysis of the stromal layer of
human heterotypic cornea substitutes generated with extra-corneal cells to determine their …

The epidermis is a stratified squamous epithelium distributed in the outermost layer of the
skin and is intimately involved in the formation of a physical barrier to pathogens. Basal …

Ectrodactyly-Ectodermal dysplasia-Clefting (EEC) syndrome is caused by heterozygous
missense point mutations in the p63 gene, an important transcription factor during …

Mesotrypsin, encoded by the PRSS3 gene, is a distinctive trypsin isoform renowned for its
exceptional resistance to traditional trypsin inhibitors and unique substrate specificity. Within …

Background/Aims: The Ectrodactyly-Ectodermal dysplasia-Clefting (EEC) and
Ankyloblepharon–ectodermal defect–cleft lip/palate (AEC) syndromes are rare autosomal …

Objective Prenatal diagnosis of the Ectrodactyly‐Ectodermal dysplasia‐clefting (EEC)
syndrome has been based upon the detection of ectrodactyly, in association with facial …

The TP63 gene is essential for epithelial proliferation, differentiation, and maintenance
during embryogenesis. Despite considerable clinical variability, TP63-related symptoms are …