Long non-coding RNA-dependent transcriptional regulation in neuronal development and disease
BS Clark, S Blackshaw - Frontiers in genetics, 2014 - frontiersin.org
Comprehensive analysis of the mammalian transcriptome has revealed that long non-
coding RNAs (lncRNAs) may make up a large fraction of cellular transcripts. Recent years …
coding RNAs (lncRNAs) may make up a large fraction of cellular transcripts. Recent years …
A central role for long non-coding RNA in cancer
Long non-coding RNAs (ncRNAs) have been shown to regulate important biological
processes that support normal cellular functions. Aberrant regulation of these essential …
processes that support normal cellular functions. Aberrant regulation of these essential …
Genes, mutations, and human inherited disease at the dawn of the age of personalized genomics
The number of reported germline mutations in human nuclear genes, either underlying or
associated with inherited disease, has now exceeded 100,000 in more than 3,700 different …
associated with inherited disease, has now exceeded 100,000 in more than 3,700 different …
[HTML][HTML] Exploring long non-coding RNAs through sequencing
SR Atkinson, S Marguerat, J Bähler - Seminars in cell & developmental …, 2012 - Elsevier
Long non-coding RNAs (lncRNAs) are emerging as an important class of regulatory
transcripts that are implicated in a variety of biological functions. RNA-sequencing, along …
transcripts that are implicated in a variety of biological functions. RNA-sequencing, along …
Long non-coding RNA in stem cell pluripotency and lineage commitment: functions and evolutionary conservation
LncRNAs have recently emerged as new and fundamental transcriptional and post-
transcriptional regulators acting at multiple levels of gene expression. Indeed, lncRNAs …
transcriptional regulators acting at multiple levels of gene expression. Indeed, lncRNAs …
Human genetics and genomics a decade after the release of the draft sequence of the human genome
Substantial progress has been made in human genetics and genomics research over the
past ten years since the publication of the draft sequence of the human genome in 2001 …
past ten years since the publication of the draft sequence of the human genome in 2001 …
Disrupted auto-regulation of the spliceosomal gene SNRPB causes cerebro–costo–mandibular syndrome
Elucidating the function of highly conserved regulatory sequences is a significant challenge
in genomics today. Certain intragenic highly conserved elements have been associated with …
in genomics today. Certain intragenic highly conserved elements have been associated with …
The most deeply conserved noncoding sequences in plants serve similar functions to those in vertebrates despite large differences in evolutionary rates
D Burgess, M Freeling - The Plant Cell, 2014 - academic.oup.com
In vertebrates, conserved noncoding elements (CNEs) are functionally constrained
sequences that can show striking conservation over> 400 million years of evolutionary …
sequences that can show striking conservation over> 400 million years of evolutionary …
[HTML][HTML] Transcribed ultraconserved noncoding RNAs (T-UCR) are involved in Barrett's esophagus carcinogenesis
M Fassan, L Dall'Olmo, M Galasso, C Braconi, M Pizzi… - Oncotarget, 2014 - ncbi.nlm.nih.gov
Barrett's esophagus (BE) involves a metaplastic replacement of native esophageal
squamous epithelium (Sq) by columnar-intestinalized mucosa, and it is the main risk factor …
squamous epithelium (Sq) by columnar-intestinalized mucosa, and it is the main risk factor …
A large scale expression study associates uc. 283-plus lncRNA with pluripotent stem cells and human glioma
Background There are 481 ultra-conserved regions (UCRs) longer than 200 bases in the
genomes of human, mouse and rat. These DNA sequences are absolutely conserved and …
genomes of human, mouse and rat. These DNA sequences are absolutely conserved and …