Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

NMDA receptors (NMDARs) are glutamate-gated ion channels and are crucial for neuronal
communication. NMDARs form tetrameric complexes that consist of several homologous …

Excitotoxicity, the specific type of neurotoxicity mediated by glutamate, may be the missing
link between ischemia and neuronal death, and intervening the mechanistic steps that lead …

PDZ domains are protein-interaction domains that are often found in multi-domain
scaffolding proteins. PDZ-containing scaffolds assemble specific proteins into large …

N-methyl-D-aspartate receptors (NMDARs) are a subtype of ionotropic glutamate receptor,
which play a central role in learning, memory, and synaptic development. NMDARs are …

The contribution of glutamate to synaptic transmission, plasticity and development is well
established; current evidence is based on diverse approaches to decipher function and …

Excitatory (glutamatergic) synapses in the mammalian brain are usually situated on dendritic
spines, a postsynaptic microcompartment that also harbors organelles involved in protein …

Activation of N-methyl-d-aspartate subtype glutamate receptors (NMDARs) is required for
long-term potentiation (LTP) and long-term depression (LTD) of excitatory synaptic …

Long-term potentiation and long-term depression are processes that have been widely
studied to understand the molecular basis of information storage in the brain. Glutamate …

The N-methyl-d-aspartate receptor (NMDAR) hypofunction hypothesis has been proposed to
help understand the etiology and pathophysiology of schizophrenia. This hypothesis was …