[HTML][HTML] Ultrasound elastography: review of techniques and clinical applications

RMS Sigrist, J Liau, A El Kaffas, MC Chammas… - Theranostics, 2017 - ncbi.nlm.nih.gov
Elastography-based imaging techniques have received substantial attention in recent years
for non-invasive assessment of tissue mechanical properties. These techniques take …

Approved antiviral drugs over the past 50 years

E De Clercq, G Li - Clinical microbiology reviews, 2016 - Am Soc Microbiol
Since the first antiviral drug, idoxuridine, was approved in 1963, 90 antiviral drugs
categorized into 13 functional groups have been formally approved for the treatment of the …

Hepatitis C virus infection

MP Manns, M Buti, ED Gane, JM Pawlotsky… - Nature reviews Disease …, 2017 - nature.com
Hepatitis C virus (HCV) is a hepatotropic RNA virus that causes progressive liver damage,
which might result in liver cirrhosis and hepatocellular carcinoma. Globally, between 64 and …

Glecaprevir and pibrentasvir in patients with HCV and severe renal impairment

E Gane, E Lawitz, D Pugatch… - … England Journal of …, 2017 - Mass Medical Soc
Background Chronic hepatitis C virus (HCV) infection is more prevalent among patients who
have chronic kidney disease than among those who do not have the disease. Patients with …

Glecaprevir plus pibrentasvir for chronic hepatitis C virus genotype 1, 2, 4, 5, or 6 infection in adults with compensated cirrhosis (EXPEDITION-1): a single-arm, open …

X Forns, SS Lee, J Valdes, S Lens, R Ghalib… - The Lancet infectious …, 2017 - thelancet.com
Background The once-daily, ribavirin-free, pangenotypic, direct-acting antiviral regimen,
glecaprevir coformulated with pibrentasvir, has shown high rates of sustained virological …

Hepatitis C virus resistance to direct-acting antiviral drugs in interferon-free regimens

JM Pawlotsky - Gastroenterology, 2016 - Elsevier
Treatment of hepatitis C virus (HCV) infection has progressed considerably with the
approval of interferon-free, direct-acting antiviral (DAA)-based combination therapies …

Outcomes after successful direct-acting antiviral therapy for patients with chronic hepatitis C and decompensated cirrhosis

MCM Cheung, AJ Walker, BE Hudson, S Verma… - Journal of …, 2016 - Elsevier
Background & Aims Direct-acting antivirals have become widely used for patients with
chronic hepatitis C virus infection with decompensated cirrhosis. Virological responses are …

Direct antiviral agent treatment of chronic hepatitis C results in rapid regression of transient elastography and fibrosis markers fibrosis‐4 score and aspartate …

JA Bachofner, PV Valli, A Kröger, I Bergamin… - Liver …, 2017 - Wiley Online Library
Background Novel direct antiviral agents (DAA) targeting hepatitis C virus (HCV) have
revolutionized the treatment of chronic hepatitis C infection (CHC). Rates of sustained …

Global epidemiology, prevention, and management of hepatocellular carcinoma

LY Mak, V Cruz-Ramón, P Chinchilla-López… - American Society of …, 2018 - ascopubs.org
The incidence rate of hepatocellular carcinoma (HCC) is rising. It is one of the most common
cancers worldwide and accounts for substantial morbidity and mortality. Chronic hepatitis B …

Host-directed therapies for infectious diseases: current status, recent progress, and future prospects

A Zumla, M Rao, RS Wallis, SHE Kaufmann… - The Lancet Infectious …, 2016 - thelancet.com
Despite extensive global efforts in the fight against killer infectious diseases, they still cause
one in four deaths worldwide and are important causes of long-term functional disability …