[HTML][HTML] Liver regeneration after acetaminophen hepatotoxicity: mechanisms and therapeutic opportunities
Acetaminophen (N-acetyl-para-aminophenol; APAP) overdose is the most common cause of
acute liver failure in the Western world, with limited treatment opportunities. For years …
acute liver failure in the Western world, with limited treatment opportunities. For years …
[HTML][HTML] Acetaminophen test battery (ATB): a comprehensive method to study acetaminophen-induced acute liver injury
Acetaminophen (APAP) overdose is the major cause of acute liver failure (ALF) in the
Western world. Extensive research is ongoing to identify the mechanisms of APAP-induced …
Western world. Extensive research is ongoing to identify the mechanisms of APAP-induced …
Dual role of epidermal growth factor receptor in liver injury and regeneration after acetaminophen overdose in mice
Epidermal growth factor receptor (EGFR) plays a crucial role in hepatocyte proliferation. Its
role in acetaminophen (APAP)-mediated hepatotoxicity and subsequent liver regeneration is …
role in acetaminophen (APAP)-mediated hepatotoxicity and subsequent liver regeneration is …
Effect of liposomal curcumin on acetaminophen hepatotoxicity by down-regulation of oxidative stress and matrix metalloproteinases
Background/Aim: The hepatoprotective role of various molecules in drug-induced
hepatotoxicity arouses great interest. We investigated the effect of liposomal curcumin (LCC) …
hepatotoxicity arouses great interest. We investigated the effect of liposomal curcumin (LCC) …
[HTML][HTML] Inhibition of glycogen synthase kinase 3 accelerated liver regeneration after acetaminophen-induced hepatotoxicity in mice
Overdose of acetaminophen (APAP) is the leading cause of acute liver failure (ALF) in the
United States. Timely initiation of compensatory liver regeneration after APAP hepatotoxicity …
United States. Timely initiation of compensatory liver regeneration after APAP hepatotoxicity …
Comparison of liver regeneration after partial hepatectomy and acetaminophen-induced acute liver failure: A global picture based on transcriptome analysis
Liver regenerates following surgical removal and after drug-induced liver injury (DILI).
However, most of the mechanisms of liver regeneration were identified using partial …
However, most of the mechanisms of liver regeneration were identified using partial …
[HTML][HTML] Integrin linked kinase (ILK) and its role in liver pathobiology
N Martucci, GK Michalopoulos, WM Mars - Gene Expression, 2021 - ncbi.nlm.nih.gov
Integrin linked kinase (ILK) is a vital signaling protein ubiquitously expressed throughout the
body. It binds to intracellular integrins to help promote signaling related to cell adhesion …
body. It binds to intracellular integrins to help promote signaling related to cell adhesion …
Energy metabolism couples hepatocyte integrin-linked kinase to liver glucoregulation and postabsorptive responses of mice in an age-dependent manner
E Trefts, CC Hughey, L Lantier… - American Journal …, 2019 - journals.physiology.org
Integrin-linked kinase (ILK) is a critical intracellular signaling node for integrin receptors. Its
role in liver development is complex, as ILK deletion at E10. 5 (before hepatocyte …
role in liver development is complex, as ILK deletion at E10. 5 (before hepatocyte …
[HTML][HTML] Regeneration and Recovery after Acetaminophen Hepatotoxicity
Liver regeneration is a compensatory response to tissue injury and loss. It is known that liver
regeneration plays a crucial role in recovery following acetaminophen (APAP)-induced …
regeneration plays a crucial role in recovery following acetaminophen (APAP)-induced …
Toll 样受体4 在对乙酰氨基酚致小鼠肝损伤过程中对肝脏再生的影响.
陈明月， 郑秀良， 乔亚琴， 沈海涛… - Journal of Clinical …, 2023 - search.ebscohost.com
目的观察抑制Toll 样受体4 (TLR4) 是否影响对乙酰氨基酚(APAP) 致小鼠肝损伤过程中的肝脏
再生, 初步探讨TLR4 参与肝脏再生的机制. 方法将78 只雄性CD r 1 小鼠采用随机数字表法分为 …
再生, 初步探讨TLR4 参与肝脏再生的机制. 方法将78 只雄性CD r 1 小鼠采用随机数字表法分为 …