Background Thiazole ring is one of the most important heterocycle scaffolds in organic and
medicinal chemistry due to this scaffold being the backbone of numerous drugs and their …

Quinazoline heterocycles are critical in the development of medications. Quinazoline
derivatives have been intensively researched, providing a wide range of compounds with …

One crucial strategy for the treatment of breast cancer involves focusing on the Vascular
Endothelial Growth Factor Receptor (VEGFR-2) signaling system. Consequently, the …

Schiff base-bearing molecules have been reported to exhibit potent biological activities;
Therefore, the synthesis and applications of these molecules are of great importance. In this …

Inflammation is a body response against infection that activates other biological components
that include various cytokines, chemokines and other biological compounds that trigger …

COX-2-selective drugs were withdrawn from the market just a few years after their
development due to cardiovascular side effects. As a result, developing a selective COX-2 …

Z-configurated isomers are kinetically preferred molecules. Compounds with Z-configuration
are contained in many natural products, biologically active compounds and as synthons for …

Cancer and inflammation interlink with many pathways. Millions of people died because of
these two disorders. Major pathways that cause both inflammation and cancer are STAT3 …

A novel series of dihydropyrimidine/sulphonamide hybrids 3a–j with anti-inflammatory
properties have been developed and tested as dual mPGES-1/5-LOX inhibitors. In vitro …

A range of fused heterocyclic compounds are generated utilizing the crucial intermediary 2-
cyano-N-(2, 5-dioxopyrrolidin-1-yl) acetamide 4. Spectral analysis was executed to support …