Chronic kidney disease (CKD) is a global health problem with rising incidence and
prevalence. Among several pathogenetic mechanisms responsible for disease progression …

The kidney is a highly metabolic organ and uses high levels of ATP to maintain electrolyte
and acid-base homeostasis and reabsorb nutrients. Energy depletion is a critical factor in …

Mild reduction in food intake was recently shown to slow polycystic kidney disease (PKD)
progression in mouse models, but whether the effect was due to solely reduced calories or …

Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common,
potentially lethal, monogenic diseases and is caused predominantly by mutations in …

Autosomal dominant polycystic kidney disease (ADPKD), caused by mutations in either
PKD1 or PKD2 genes, is one of the most common human monogenetic disorders and the …

More than 800 million people suffer from kidney disease. Genetic studies and follow-up
animal models and cell biological experiments indicate the key role of proximal tubule …

Autosomal dominant polycystic kidney disease (ADPKD) is a common monogenic disorder
marked by numerous progressively enlarging kidney cysts. Mettl3, a methyltransferase that …

Short-chain chlorinated paraffins (SCCPs) are ubiquitously distributed in various
environmental matrics due to their wide production and consumption globally in the past and …

Polycystic liver diseases (PLDs) are inherited genetic disorders characterized by
progressive development of intrahepatic, fluid-filled biliary cysts (more than ten), which …

Epithelial tissues provide front-line barriers shielding the organism from invading pathogens
and harmful substances. In the airway epithelium, the combined action of multiciliated and …