p21 functions as a cell cycle inhibitor and anti-proliferative effector in normal cells, and is
dysregulated in some cancers. Earlier observations on p21 knockout models emphasized …

Cancer stem cells (CSCs) are one of the reasons for the relapse of cancer cells and
metastasis. They have drug resistance against most chemotherapeutic agents. CSCs are …

Dental pulp stem cells (DPSC) are capable of differentiating into vascular endothelial cells.
Although the capacity of vascular endothelial growth factor (VEGF) to induce endothelial …

Since its discovery over 35 years ago, MDM2 has emerged as an attractive target for the
development of cancer therapy. MDM2's activities extend from carcinogenesis to immunity to …

The pathological changes and possible underlying molecular mechanisms of hepatocellular
carcinoma (HCC) are currently unclear. Effective treatment of this pathological state remains …

Background Human malignancies are composed of heterogeneous subpopulations of
cancer cells with phenotypic and functional diversity. Among them, a unique subset of …

Purpose: Mucoepidermoid carcinoma (MEC) is a poorly understood salivary gland
malignancy with limited therapeutic options. Cancer stem cells (CSC) are considered drivers …

Endometrial cancer (EC) is the third leading gynecological malignancy, and its treatment
remains challenging. B cell-specific Moloney murine leukemia virus integration site-1 (BMI1) …

Ubiquitin modification plays significant roles in protein fate determination, signaling
transduction, and cellular processes. Over the past 2 decades, the number of studies on …

Simple Summary Cancer stem cells (CSCs) are known to be highly resistant to conventional
therapeutic approaches, such as chemotherapeutic drugs and radiation. Therefore …