Background Chronic pain conditions impose significant burdens worldwide.
Pharmacological treatments like opioids have limitations. Non-invasive non …

Capsaicin, the pungent ingredient in chili peppers, produces intense burning pain in
humans. Capsaicin selectively activates the transient receptor potential vanilloid 1 (TRPV1) …

Wound healing is a largely unmet medical issue in trauma, burn, and diabetes. In this study,
a pullulan-based and nanoparticle-loaded smart microneedle patch is designed to release …

Chronic orofacial pain conditions can be particularly difficult to diagnose and treat because
of their complexity and limited understanding of the mechanisms underlying their aetiology …

The persistence of increased excitability and spontaneous activity in injured peripheral
neurons is imperative for the development and persistence of many forms of neuropathic …

Intractable neuropathic pain is a frequent consequence of nerve injury or disease. When
peripheral nerves are injured, damaged axons undergo Wallerian degeneration. Schwann …

Microglia is a heterogeneous population that mediates neuroinflammation in the central
nervous system (CNS) and plays a crucial role in developing neuropathic pain. FKBP5 …

Introduction The primary objective of this paper is to (1) provide a summary of human studies
that have used brain derived neurotrophic factor (BDNF) as a biomarker,(2) review animal …

Pain is one of the main problems for modern society and medicine, being the most common
symptom described by almost all patients. When pain becomes chronic, the life of the …

Transient receptor potential vanilloid 1 (TRPV1) channels are widely distributed in sensory
nerve endings, the central nervous system, and other tissues, functioning as ion channel …