SLC7A5, known as LAT1, belongs to the APC superfamily and forms a heterodimeric amino
acid transporter interacting with the glycoprotein CD98 (SLC3A2) through a conserved …

Amino acids are necessary for all living cells and organisms. Specialized transporters
mediate the transfer of amino acids across plasma membranes. Malfunction of these …

Cysteine plays an essential role in cellular redox homoeostasis as a key constituent of the
tripeptide glutathione (GSH). A rate limiting step in cellular GSH synthesis is the availability …

Brain exposure of systemically administered biotherapeutics is highly restricted by the blood-
brain barrier (BBB). Here, we report the engineering and characterization of a BBB transport …

The L-type amino acid transporter 1 (LAT1; also known as SLC7A5) catalyses the cross-
membrane flux of large neutral amino acids in a sodium-and pH-independent manner …

Thyroid hormone transporters at the plasma membrane govern intracellular bioavailability of
thyroid hormone. Monocarboxylate transporter (MCT) 8 and MCT10, organic anion …

Abstract α-Amylase (EC 3.2. 1.1) represents the best known amylolytic enzyme. It catalyzes
the hydrolysis of α-1, 4-glucosidic bonds in starch and related α-glucans. In general, the α …

Glutamine together with glucose is essential for body's homeostasis. It is the most abundant
amino acid and is involved in many biosynthetic, regulatory and energy production …

The small intestine mediates the absorption of amino acids after ingestion of protein and
sustains the supply of amino acids to all tissues. The small intestine is an important …

The L-type amino acid transporter 1 (LAT1 or SLC7A5) transports large neutral amino acids
across the membrane and is crucial for brain drug delivery and tumor growth. LAT1 forms a …