Advanced prostate cancers that progress to tumor metastases are often considered
incurable or difficult to treat. The etiology of prostate cancers is multi-factorial. Among other …

Simple Summary Regucalcin plays a multifunctional role in the regulation of cell function
and expresses a repressive effect in the growth of normal cells. Of note, there is increasing …

Survival and inhibitory factors regulate steroidogenesis and determine the fate of developing
follicles. The objective of this study was to determine the role of transforming growth factor …

Prostate cancer (PCa) progresses from an early stage, confined to prostate, to a more
aggressive metastasized cancer related with loss of androgen responsiveness. Although, it …

Purpose The present study aims to investigate the role of androgens in controlling the
glycolytic metabolism and lactate efflux in prostate cancer (PCa) cells. Methods Androgen …

Abstract Purpose: Endoscopic surveillance of Barrett's esophagus is problematic because
dysplasia/early-stage neoplasia is frequently invisible and likely to be missed because of …

Prostate cancer is one of the leading causes of mortality in men. The major cause of death in
prostate cancer patients can be attributed to metastatic spread of disease or tumor …

Abstract Regucalcin (RGN/SMP30) was discovered in 1978 and is a unique calcium‐
binding protein contains no EF‐hand motif calcium‐binding domain. Its name, regucalcin …

Intracellular calcium excess as one of the main factors in the etiology of prostate cancer
Page 1 AIMS Molecular Science, 3(4): 635-647. DOI: 10.3934/molsci.2016.4.635 Received …

Calcium ions (Ca2+) act as second messengers in intracellular signaling. Ca2+ pumps,
channels, sensors, and calcium binding proteins, regulate the concentrations of intracellular …