An aspirin a day: new pharmacological developments and cancer chemoprevention
DG Menter, RS Bresalier - Annual Review of Pharmacology and …, 2023 - annualreviews.org
Chemoprevention refers to the use of natural or synthetic agents to reverse, suppress, or
prevent the progression or recurrence of cancer. A large body of preclinical and clinical data …
prevent the progression or recurrence of cancer. A large body of preclinical and clinical data …
Refining colorectal cancer classification and clinical stratification through a single-cell atlas
Background Colorectal cancer (CRC) consensus molecular subtypes (CMS) have different
immunological, stromal cell, and clinicopathological characteristics. Single-cell …
immunological, stromal cell, and clinicopathological characteristics. Single-cell …
Epigenetic perspective of immunotherapy for cancers
Immunotherapy has brought new hope for cancer patients in recent times. However, despite
the promising success of immunotherapy, there is still a need to address major challenges …
the promising success of immunotherapy, there is still a need to address major challenges …
Profiling the heterogeneity of colorectal cancer consensus molecular subtypes using spatial transcriptomics
A Valdeolivas, B Amberg, N Giroud… - NPJ precision …, 2024 - nature.com
The consensus molecular subtypes (CMS) of colorectal cancer (CRC) is the most widely-
used gene expression-based classification and has contributed to a better understanding of …
used gene expression-based classification and has contributed to a better understanding of …
Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes
Genome-wide association studies (GWAS) have identified more than 200 common genetic
variants independently associated with colorectal cancer (CRC) risk, but the causal variants …
variants independently associated with colorectal cancer (CRC) risk, but the causal variants …
CUL4B-DDB1-COP1-mediated UTX downregulation promotes colorectal cancer progression
D Luo, M Chen, Q Li, K Wang, K Wang, J Li… - … Hematology & Oncology, 2023 - Springer
Background UTX (encoded by KDM6A), a histone demethylase for H3K27me2/3, is
frequently mutated in human cancers. However, its functional and regulatory mechanisms in …
frequently mutated in human cancers. However, its functional and regulatory mechanisms in …
An epigenetic signature of advanced colorectal cancer metastasis
EJ Rodger, G Gimenez, P Ajithkumar, PA Stockwell… - IScience, 2023 - cell.com
Colorectal cancer (CRC) is a leading cause of morbidity and mortality worldwide. The
majority of CRC deaths are caused by tumor metastasis, even following treatment. There is …
majority of CRC deaths are caused by tumor metastasis, even following treatment. There is …
A distal super-enhancer activates oncogenic ETS2 via recruiting MECOM in inflammatory bowel disease and colorectal cancer
Y Chen, Y Ying, M Wang, C Ma, M Jia, L Shi… - Cell Death & …, 2023 - nature.com
Abnormal activities of distal cis-regulatory elements (CREs) contribute to the initiation and
progression of cancer. Gain of super-enhancer (SE), a highly active distal CRE, is essential …
progression of cancer. Gain of super-enhancer (SE), a highly active distal CRE, is essential …
A Ctnnb1 enhancer transcriptionally regulates Wnt signaling dosage to balance homeostasis and tumorigenesis of intestinal epithelia
The β-catenin-dependent canonical Wnt signaling is pivotal in organ development, tissue
homeostasis, and cancer. Here, we identified an upstream enhancer of Ctnnb1–the coding …
homeostasis, and cancer. Here, we identified an upstream enhancer of Ctnnb1–the coding …
G protein-coupled receptor-targeting antibody-drug conjugates: Current status and future directions
In recent years, antibody-drug conjugates (ADCs) have emerged as promising anti-cancer
therapeutic agents with several having already received market approval for the treatment of …
therapeutic agents with several having already received market approval for the treatment of …