Respiratory viruses are real menace for human health which result in devastating epidemic
disease. Consequently, it is in urgent need of identifying and quantifying virus with a rapid …

The choice of biosensing elements is crucial for the development of the optimal biosensor.
Three of the most versatile biosensing elements are antibody single-chain Fv fragments …

The recognition of foreign antigens by T lymphocytes is essential to most adaptive immune
responses. It is driven by specific T-cell antigen receptors (TCRs) binding to antigenic …

Arginine has been used to suppress protein aggregation and protein–protein or protein–
surface interactions during protein refolding and purification. While its biotechnology …

Recombinant proteins are often expressed in the form of insoluble inclusion bodies in
bacteria. To facilitate refolding of recombinant proteins obtained from inclusion bodies, 0.1 to …

Refolding of proteins from inclusion bodies is affected by several factors, including
solubilization of inclusion bodies by denaturants, removal of the denaturant, and assistance …

Antibodies and antibody derivatives constitute 20% of biopharmaceutical products currently
in development, and despite early failures of murine products, chimeric and humanized …

Arginine is one of the universal reagents that are effective in assisting refolding of
recombinant proteins from inclusion bodies. The mechanism of the effects of arginine on …

This paper overviews solution additives that affect protein stability and aggregation during
refolding, heating, and freezing processes. Solution additives are mainly grouped into two …

Many successful, recent therapies for life-threatening diseases such as cancer and
rheumatoid arthritis are based on the recognition between native or genetically engineered …