Neurodevelopmental disorders arise due to various risk factors that can perturb different
stages of brain development, and a combinatorial impact of these risk factors programs the …

The cerebral cortex is the brain's outermost layer. It is responsible for processing motor and
sensory information that support high-level cognitive abilities and shape personality. Its …

The adult human brain comprises more than a thousand distinct neuronal and glial cell
types, a diversity that emerges during early brain development. To reveal the precise …

Progression through fate decisions determines cellular composition and tissue architecture,
but how that same architecture may impact cell fate is less clear. We took advantage of …

Late prenatal development of the human neocortex encompasses a critical period of
gliogenesis and cortical expansion. However, systematic single-cell analyses to resolve …

Abstract Histone 3 lysine27-to-methionine (H3-K27M) mutations most frequently occur in
diffuse midline gliomas (DMGs) of the childhood pons but are also increasingly recognized …

The intracellular cholesterol transporter NPC1 functions in late endosomes and lysosomes
to efflux unesterified cholesterol, and its deficiency causes Niemann–Pick disease Type C …

Thyroid hormones (TH) play critical roles during nervous system development and patients
carrying coding variants of MCT8 (monocarboxylate transporter 8) or THRA (thyroid …

Elucidating spatiotemporal changes in gene expression has been an essential goal in
studies of health, development, and disease. In the emerging field of spatially resolved …

Oligodendrocytes originating in the brain and spinal cord as well as in the ventral and dorsal
domains of the neural tube are transcriptomically and functionally distinct. These distinctions …