The pathogeneses of the 2 major forms of diabetes, type 1 and type 2, differ with respect to
their major molecular insults (loss of immune tolerance and onset of tissue insulin …

Arginase is a ubiquitous enzyme in the urea cycle (UC) that hydrolyzes L‐arginine to urea
and L‐ornithine. Two mammalian arginase isoforms, arginase1 (ARG1) and arginase2 …

Diabetes mellitus (DM) is a frequent medical problem, affecting more than 4% of the
population in most countries. In the context of diabetes, the vascular endothelium can play a …

In preclinical models, α-difluoromethylornithine (DFMO), an ornithine decarboxylase (ODC)
inhibitor, delays the onset of type 1 diabetes (T1D) by reducing β cell stress. However, the …

Background Aging-related energy homeostasis significantly affects normal heart function
and disease development. The relationship between the gut microbiota and host energy …

Glycemic variability (GV) in some patients with type 1 diabetes (T1D) remains
heterogeneous despite comparable clinical indicators, and whether other factors are …

Diabetes mellitus (DM) is a frequent medical problem, affecting more than 4% of the
population in most countries. In the context of diabetes, the vascular endothelium can play a …

Metformin is the first-line treatment for type 2 diabetes, yet its mechanism of action is not fully
understood. Recent studies suggest metformin's interactions with gut microbiota are …

Diabetes, a severe metabolic disease characterized by chronic hypoglycemia, poses
debilitating and life-threatening risks of microvascular and macrovascular complications …

The major intracellular polyamines spermine and spermidine are abundant and ubiquitous
compounds that are essential for cellular growth and development. Spermine catabolism is …