Drug design is a process which is driven by technological breakthroughs implying advanced
experimental and computational methods. Nowadays, the techniques or the drug design …

Boron is ubiquitous in nature, being an essential element of diverse cells. As a result,
humans have had contact with boron containing compounds (BCCs) for a long time. During …

Molecular docking has been developed and improving for many years, but its ability to bring
a medicine to the drug market effectively is still generally questioned. In this chapter, we …

CDK2, which interacts with cyclin A and cyclin E, is an important member of the CDK family.
Having been proved to be associated with many diseases for its vital role in cell cycle, CDK2 …

Type 2 diabetes is becoming a global pandemic disease. As an important target for the
generation and development of diabetes mellitus, peroxisome proliferator-activated receptor …

Background: Mantle cell lymphoma (MCL) is a type of non-Hodgkin lymphoma characterized
by the mutation and overexpression of the cyclin D1 protein by the reciprocal chromosomal …

JNK1 has been suggested to play a key mediator in metabolic disorders, especially been
considered to be a drug target for treatment of type-2 diabetes in recent years. Therefore …

In the current work, computational methods were used to investigate new isoxazole
derivatives that could be used as tubulin inhibitors. The study aims to develop a reliable …

BRD4 plays an indispensable role in cell cycle regulation, affecting processes such as cell
proliferation, apoptosis and transcription. In this article, a three‐dimensional quantitative …

Environmental estrogens have attracted great concerns. Recent studies have indicated that
some hydroxylated polybrominated diphenyl ethers (HO-PBDEs) can interact with estrogen …