The systematic bioanalytical characterization of the protein product of the DMD gene, which
is defective in the pediatric disorder Duchenne muscular dystrophy, led to the discovery of …

Caveolae are the cholesterol-rich small invaginations of the plasma membrane present in
many cell types including adipocytes, endothelial cells, epithelial cells, fibroblasts, smooth …

Major depressive disorder is a complex disease resulting from aberrant synaptic plasticity
that may be caused by abnormal serotonergic signaling. Using a combination of behavioral …

Alzheimer's disease (AD) is an age-related progressive neurodegenerative disease, and
approximately 10% of AD cases are early-onset familial AD (EOFAD), which is mainly linked …

Proper muscle function depends on the neuromuscular junctions (NMJs), which mature
postnatally to complex “pretzel-like” structures, allowing for effective synaptic transmission …

Background: Fat is a tissue that not just stores energy and plays a protective role; it is also a
vital endocrine organ that generates and integrates signals to influence metabolism …

Rho guanine nucleotide exchange factors (Rho GEFs) activate Rho GTPases, which act as
molecular switches regulating various essential cellular functions. This study investigated …

Neuromuscular junctions transmit signals from the nervous system to skeletal muscles,
triggering their contraction, and their proper organization is essential for breathing and …

Currently, the etiology of many neuromuscular disorders remains unknown. Many of them
are characterized by aberrations in the maturation of the neuromuscular junction (NMJ) …

The neuromuscular junction (NMJ) is the peripheral synapse formed between a motor axon
and a skeletal muscle fibre that allows muscle contraction and the coordinated movement in …