Microbial pathogens possess an arsenal of strategies to invade their hosts, evade immune
defences and promote infection. In particular, bacteria use virulence factors, such as …

Intestinal epithelial cells provide an essential line of defense for Caernohabditis elegans
against ingested pathogens. Because nematodes consume microorganisms as their food …

Caenorhabditis elegans must distinguish pathogens from nutritious food sources among the
many bacteria to which it is exposed in its environment. Here we show that a single …

Most Caenorhabditis elegans studies have used laboratory Escherichia coli as diet and
microbial environment. Here we characterize bacteria of C. elegans' natural habitats of …

Metazoans identify and eliminate bacterial pathogens in microbe-rich environments such as
the intestinal lumen; however, the mechanisms are unclear. Host cells could potentially use …

The nematode C. elegans is attracted to nutritious bacteria and is repelled by pathogens
and toxins. Here we show that RNAi and toxin-mediated disruption of core cellular activities …

Mitochondrial function is challenged by toxic by-products of metabolism as well as by
pathogen attack,. Caenorhabditis elegans normally responds to mitochondrial dysfunction …

The genetically tractable model host Caenorhabditis elegans provides a valuable tool to
dissect host-microbe interactions in vivo. Pseudomonas aeruginosa and Staphylococcus …

The ability to detect, respond and adapt to mitochondrial stress ensures the development
and survival of organisms. Caenorhabditis elegans responds to mitochondrial stress by …

In the arms race of bacterial pathogenesis, bacteria produce an array of toxins and virulence
factors that disrupt core host processes. Hosts mitigate the ensuing damage by responding …