Osteosarcoma is a primary bone malignancy with a particularly high incidence rate in
children and adolescents relative to other age groups. The etiology of this often aggressive …

Osteosarcoma is an aggressive cancer in skeletal system with unknown molecular
mechanisms of etiology and pathogenesis, therefore it remains a challenge for current …

Runt-related transcription factor 2 (RUNX2) is an osteogenesis-related transcription factor
that has emerged as a prominent transcription repressing factor in carcinogenesis. However …

Background Osteosarcomas are the most common primary malignant tumors of bone and
show multiple and complex genomic aberrations. miRNAs are non-coding RNAs capable of …

Osteosarcoma is an aggressive but ill‐understood cancer of bone that predominantly affects
adolescents. Its rarity and biological heterogeneity have limited studies of its molecular …

Runt-related transcription factor (RUNX) proteins belong to a transcription factors family
known as master regulators of important embryonic developmental programs. In the last …

Osteosarcoma (OS) is the most common primary malignant bone tumor in children and
adolescents. It is characterized by highly complex karyotypes with structural and numerical …

[Frontiers in Bioscience 17, 331-348, January 1, 2012] 331 WW domain-containing proteins:
Retrospectives and the future Zaidoun Page 1 [Frontiers in Bioscience 17, 331-348, January …

Runx2 regulates osteogenic differentiation and bone formation, but also suppresses pre‐
osteoblast proliferation by affecting cell cycle progression in the G1 phase. The growth …

Recent studies have clearly linked nuclear factor-kappaB (NF-κB), a transcription factor that
plays a central role in regulating immune and inflammatory responses, to tumor …