The action potential of the squid giant axon is formed by just two voltage-dependent
conductances in the cell membrane, yet mammalian central neurons typically express more …

Swallowing movements are produced by a central pattern generator located in the medulla
oblongata. It has been established on the basis of microelectrode recordings that the …

Members of a previously unidentified family of potassium channel subunits were cloned from
rat and human brain. The messenger RNAs encoding these subunits were widely expressed …

Movement is accomplished by the controlled activation of motor unit populations. Our
understanding of motor unit physiology has been derived from experimental work on the …

Action potentials in neurones are followed by a hyperpolarization, which can last up to
several seconds. This hyperpolarization has several phases that are mediated by the …

Movement, the fundamental component of behavior and the principal extrinsic action of the
brain, is produced when skeletal muscles contract and relax in response to patterns of action …

Layer V pyramidal neurons are anatomically and physiologically heterogeneous and project
to multiple intracortical and subcortical targets. However, because most physiological …

Damage to the nervous system can cause neuropathic pain, which is in general poorly
treated and involves mechanisms that are incompletely known. Currently available animal …

In hippocampal pyramidal cells, a single action potential (AP) or a burst of APs is followed by
a medium afterhyperpolarization (mAHP, lasting∼ 0.1 s). The currents underlying the mAHP …

The gene for hSK4, a novel human small conductance calcium-activated potassium
channel, or SK channel, has been identified and expressed in Chinese hamster ovary cells …