The transition to compulsion in addiction
Compulsion is a cardinal symptom of drug addiction (severe substance use disorder).
However, compulsion is observed in only a small proportion of individuals who repeatedly …
However, compulsion is observed in only a small proportion of individuals who repeatedly …
Dopamine: functions, signaling, and association with neurological diseases
The dopaminergic system plays important roles in neuromodulation, such as motor control,
motivation, reward, cognitive function, maternal, and reproductive behaviors. Dopamine is a …
motivation, reward, cognitive function, maternal, and reproductive behaviors. Dopamine is a …
The nucleus accumbens: a comprehensive review
S Salgado, MG Kaplitt - Stereotactic and functional neurosurgery, 2015 - karger.com
There is increasing interest among functional neurosurgeons in the potential for novel
therapies to impact upon diseases beyond movement disorders and pain. A target of …
therapies to impact upon diseases beyond movement disorders and pain. A target of …
[HTML][HTML] Rethinking the emotional brain
J LeDoux - Neuron, 2012 - cell.com
I propose a reconceptualization of key phenomena important in the study of emotion—those
phenomena that reflect functions and circuits related to survival, and that are shared by …
phenomena that reflect functions and circuits related to survival, and that are shared by …
The nucleus accumbens: an interface between cognition, emotion, and action
SB Floresco - Annual review of psychology, 2015 - annualreviews.org
Nearly 40 years of research on the function of the nucleus accumbens (NAc) has provided a
wealth of information on its contributions to behavior but has also yielded controversies and …
wealth of information on its contributions to behavior but has also yielded controversies and …
Cerebellar networks with the cerebral cortex and basal ganglia
The dominant view of cerebellar function has been that it is exclusively concerned with
motor control and coordination. Recent findings from neuroanatomical, behavioral, and …
motor control and coordination. Recent findings from neuroanatomical, behavioral, and …
[HTML][HTML] From the ventral to the dorsal striatum: devolving views of their roles in drug addiction
BJ Everitt, TW Robbins - Neuroscience & Biobehavioral Reviews, 2013 - Elsevier
We revisit our hypothesis that drug addiction can be viewed as the endpoint of a series of
transitions from initial voluntarily drug use to habitual, and ultimately compulsive drug use …
transitions from initial voluntarily drug use to habitual, and ultimately compulsive drug use …
[HTML][HTML] Human and rodent homologies in action control: corticostriatal determinants of goal-directed and habitual action
BW Balleine, JP O'doherty - Neuropsychopharmacology, 2010 - nature.com
Recent behavioral studies in both humans and rodents have found evidence that
performance in decision-making tasks depends on two different learning processes; one …
performance in decision-making tasks depends on two different learning processes; one …
A selective role for dopamine in stimulus–reward learning
Individuals make choices and prioritize goals using complex processes that assign value to
rewards and associated stimuli. During Pavlovian learning, previously neutral stimuli that …
rewards and associated stimuli. During Pavlovian learning, previously neutral stimuli that …
Neural systems of reinforcement for drug addiction: from actions to habits to compulsion
BJ Everitt, TW Robbins - Nature neuroscience, 2005 - nature.com
Drug addiction is increasingly viewed as the endpoint of a series of transitions from initial
drug use—when a drug is voluntarily taken because it has reinforcing, often hedonic, effects …
drug use—when a drug is voluntarily taken because it has reinforcing, often hedonic, effects …