GAERF: predicting lncRNA-disease associations by graph auto-encoder and random forest

QW Wu, JF Xia, JC Ni, CH Zheng - Briefings in bioinformatics, 2021 - academic.oup.com
Predicting disease-related long non-coding RNAs (lncRNAs) is beneficial to finding of new
biomarkers for prevention, diagnosis and treatment of complex human diseases. In this …

CeDR Atlas: a knowledgebase of cellular drug response

YY Wang, H Kang, T Xu, L Hao, Y Bao… - Nucleic acids …, 2022 - academic.oup.com
Drug response to many diseases varies dramatically due to the complex genomics and
functional features and contexts. Cellular diversity of human tissues, especially tumors, is …

[HTML][HTML] An explainable framework for drug repositioning from disease information network

C He, L Duan, H Zheng, L Song, M Huang - Neurocomputing, 2022 - Elsevier
Exploring efficient and high-accuracy computational drug repositioning methods has
become a popular and attractive topic in drug development. This technology can …

LW-AFC, a new formula from the traditional Chinese medicine liuwei dihuang decoction, as a promising therapy for alzheimer's disease: Pharmacological effects and …

X Cheng, Y Huang, Y Zhang, W Zhou - Advances in pharmacology, 2020 - Elsevier
LW-AFC is a new formula derived from the Liuwei Dihuang decoction, a classical traditional
Chinese medicine prescription. Based on our research, LW-AFC is a promising drug for …

Characteristics of the traditional Liu-Wei-Di-Huang prescription reassessed in modern pharmacology

XR Cheng, QI Chun-Hui, W Tong-Xing… - Chinese journal of …, 2019 - Elsevier
Abstract Liu-Wei-Di-Huang (LW) is a Yin nourishing and kidney tonifying prescription in
traditional Chinese medicine with promising pharmacological characteristics that can be …

[HTML][HTML] Network pharmacology identifies the mechanisms of action of TaohongSiwu decoction against essential hypertension

T Liu, W Chen, X Chen, Q Liang, W Tao… - … Medical Journal of …, 2020 - ncbi.nlm.nih.gov
Background TaohongSiwu decoction (THSWT), a traditional herbal formula, has been used
to treat cardiovascular and cerebrovascular diseases such as essential hypertension (EH) in …

Anti-apoptosis mechanism of triptolide based on network pharmacology in focal segmental glomerulosclerosis rats

Y Li, X Jiang, L Song, M Yang, J Pan - Bioscience Reports, 2020 - portlandpress.com
Triptolide (TPL), the active component of Tripterygium wilfordii, exhibits anti-cancer and
antioxidant functions. We aimed to explore the anti-apoptosis mechanism of TPL based on …

Network Pharmacology with Metabolomics Study to Reveal the Mechanisms of Bushen Huoxue Formula in Intervertebral Disc Degeneration Treatment

J Guo, S Yang, W Zhai, Y Xie, Z Shen… - Drug Design …, 2024 - Taylor & Francis
Background Intervertebral disc degeneration (IVDD) is a pathophysiological process that
leads to severe back pain or neurological deficits. The Bushen Huoxue Formula (BSHXF) is …

Calculating the similarity between prescriptions to find their new indications based on graph neural network

X Han, X Xie, R Zhao, Y Li, P Ma, H Li, F Chen… - Chinese Medicine, 2024 - Springer
Background Drug repositioning has the potential to reduce costs and accelerate the rate of
drug development, with highly promising applications. Currently, the development of artificial …

AIM in Alternative Medicine

Z Shu, T Jia, H Tian, D Yan, Y Yang, X Zhou - Artificial Intelligence in …, 2020 - Springer
Alternative medicine (AM) is one of the medical fields that use more natural and traditional
therapies for disease diagnosis and treatment, in which traditional Chinese medicine (TCM) …