Spermiogenesis is a complex cellular differentiation process that the germ cells undergo a
distinct morphological change, and the protamines replace the core histones to facilitate …

OBJECTIVE: To review and summarize the current understanding of the epigenetic status of
human sperm in regards to protamination, specific localization and modifications of retained …

Male germ cell differentiation is a highly regulated multistep process initiated by the
commitment of progenitor cells into meiosis and characterized by major chromatin …

Male infertility is a common and complex problem affecting 1 in 20 men. Despite voluminous
research in this field, in many cases, the underlying causes are unknown. Epigenetic factors …

Brdt is a testis-specific member of the distinctive BET sub-family of bromodomain motif-
containing proteins, a motif that binds acetylated lysines and is implicated in chromatin …

NUT midline carcinoma (NMC), an aggressive form of squamous cell carcinoma, is defined
by the presence of acquired chromosomal rearrangements involving NUT, usually BRD4 …

Multiple circuitries ensure that cells respond correctly to the environmental cues within
defined cellular programs. There is increasing evidence suggesting that cellular memory for …

Bisphenol A (BPA) is an environmental endocrine disruptor. Recent studies have shown an
association between decreased spermatogenesis and gut microbiota alteration. However …

In a subset of poorly differentiated and highly aggressive carcinoma, a chromosomal
translocation, t (15; 19)(q13; p13), results in an in‐frame fusion of the double bromodomain …

Spermiogenesis is a long process whereby haploid spermatids derived from the meiotic
divisions of spermatocytes undergo metamorphosis into spermatozoa. It is subdivided into …