Alcohol use disorder (AUD) is a highly prevalent, comorbid, and disabling disorder. The
underlying mechanism of ethanol neurotoxicity and the involvement of oxidative stress is still …

Abstract Mu-Opioid Receptors (MORs) are well-known for participating in analgesia,
sedation, drug addiction, and other physiological functions. Although MORs have been …

Alcohol is one of the most widely used substances. Alcohol use accounts for 5.1% of the
global disease burden, contributes substantially to societal and economic costs, and leads …

The consumption of alcohol and caffeine affects the lives of billions of individuals worldwide.
Although recent evidence indicates that caffeine impairs the reinforcing properties of …

Cardiovascular illnesses remain the primary cause of death, accounting for at least 17.9
million fatalities per year and posing a significant public health problem because of its …

Hepatitis B virus (HBV) and alcohol abuse often contribute to the development of end-stage
liver disease. Alcohol abuse not only causes rapid progression of liver disease in HBV …

Disorders such as pancreatic or hepatic fibrosis are a cruel reminder that disruption of the
delicate physiological balance could result in severe pathological consequences. Fibrosis is …

Excessive alcohol consumption is one of the most significant causes of morbidity and
mortality worldwide. Alcohol is oxidized to toxic and carcinogenic acetaldehyde by alcohol …

Excessive intake of ethanol is associated with severe brain dysfunction, and the subsequent
neurological and behavioral abnormalities are well-established social risks. Many research …

Abnormal consumption of ethanol, the ingredient responsible for alcoholic drinks' addictive
liability, causes millions of deaths yearly. Ethanol's addictive potential is triggered through …