Advances in sequencing and high-throughput techniques have provided an unprecedented
opportunity to interrogate human diseases on a genome-wide scale. The list of disease …

Ribosomopathies are diseases caused by defects in ribosomal constituents or in factors with
a role in ribosome assembly. Intriguingly, congenital ribosomopathies display a paradoxical …

Introduction Plummeting sequencing costs have led to a great increase in the number of
personal genomes. Interpreting the large number of variants in them, particularly in …

The role of RNA polymerase (Pol) III in eukaryotic transcription is commonly thought of as
being restricted to a small set of highly expressed, housekeeping non–protein-coding (nc) …

The complex aspects linking the nucleolus and ribosome biogenesis to cancer are reviewed
here. The available evidence indicates that the morphological and functional changes in the …

p53 inactivation is highly associated with tumorigenesis and drug resistance. Here, we
identify a long noncoding RNA, the RNA component of mitochondrial RNA-processing …

RNA polymerase (Pol) III is responsible for transcription of different noncoding genes in
eukaryotic cells, whose RNA products have well-defined functions in translation and other …

Nuclear ribonuclease (RNase) P is a ubiquitous essential ribonucleoprotein complex, one of
only two known RNA-based enzymes found in all three domains of life. The RNA component …

Ribosomes are perhaps the most critical macromolecular machine as they are tasked with
carrying out protein synthesis in cells. They are incredibly complex structures composed of …

Ribosomes are vital for cell growth and survival. Until recently, it was believed that mutations
in ribosomes or ribosome biogenesis factors would be lethal, due to the essential nature of …