The D1-like (D1, D5) and D2-like (D2, D3, D4) classes of dopamine receptors each has
shared signaling properties that contribute to the definition of the receptor class, although …

The evolution of the vertebrate kidney records three occasions, each separated by about 50
million years, when fish have abandoned glomeruli to produce urine by tubular …

Dopamine D1-like receptors consisting of D1 and D5 subtypes are intimately implicated in
dopaminergic regulation of fundamental neurophysiologic processes such as mood …

Our previous work indicated that the subfornical organ (SFO) is an important brain sensor of
blood-borne proinflammatory cytokines, mediating their central effects on autonomic and …

Abnormalities in dopamine production and receptor function have been described in human
essential hypertension and rodent models of genetic hypertension. Under normal …

Transport of organic cations (OC) is important for the recycling of endogenous OC and also
a necessary step for detoxification of exogenous OC in the body. Even though the …

In this review, we outline the application and contribution of transgenic technology to
establishing the genetic basis of blood pressure regulation and its dysfunction. Apart from a …

Cardiac glycosides have been widely used in the treatment of congestive heart failure and
cardiac arrhythmias. The mechanism of their positive ionotropic effect is well characterized …

Background and Purpose The function of the endocannabinoid system (ECS) in renal tissue
is not completely understood. Kidney function is closely related to ion reabsorption in the …

Neurodegenerative disorders possess common pathological mechanisms, such as protein
aggregation, inflammation, oxidative stress (OS) and excitotoxicity, raising the possibility of …