Phaeochromocytomas and paragangliomas (PPGLs) are neural-crest-derived tumours of
the sympathetic or parasympathetic nervous system that are often inherited and are …

Abstract Purpose of Review Pheochromocytomas and paragangliomas (PPGLs) are
uncommon catecholamine-producing neuroendocrine neoplasms that usually present with …

Genetic diagnosis is recommended for all pheochromocytoma and paraganglioma (PPGL)
cases, as driver mutations are identified in approximately 80% of the cases. As the list of …

Activity of the Highly Specific RET Inhibitor Selpercatinib (LOXO-292) in Pediatric Patients With
Tumors Harboring RET Gene Alterations - PMC Back to Top Skip to main content NIH NLM …

Aberrant activation of the RET proto-oncogene is implicated in a plethora of cancers. RET
gain-of-function point mutations are driver events in multiple endocrine neoplasia 2 (MEN2) …

2016/0102097 A1 2017/0014413 A1 2017/0022206 A1 2017/0029409 A1 2017/0057953
A1 2017/0066773 A1 2017/0066812 A1 2017/0121312 Al 2017/0145018 A1 2017/0174652 …

2013/0096136 Al 4/2013 Hata et al. 2013/0115313 Al 5/2013 Charrier et al. 2013/0116280
A1 5/2013 Ju et al. 2014/0187559 Al 7/2014 Miduturu 2014/0221404 A1 8/2014 Kohno et al …

Increasing body of recent studies determining the expression of tumor-specific major
histocompatibility complex (MHC) class II protein supports its potential role in several …

Described herein are compounds, such as compounds of Formula (I) and pharmaceutically
acceptable salts thereof, that inhibit wild-type RET and its resistant mutants, phar maceutical …

Background Different pathogenic germline mutations in the RET o ncogene are identified in
MEN 2, a hereditary syndrome characterized by medullary thyroid carcinoma (MTC) and …