Drug resistance is mainly responsible for cancer recurrence and poor prognosis. Epigenetic
regulation is a heritable change in gene expressions independent of nucleotide sequence …

Small cell lung cancer (SCLC) is a type of neuroendocrine tumor with high malignancy and
poor prognosis. Besides the de novo SCLC, there is transformed SCLC, which has similar …

Breast cancer is the most prevalent cancer in the world. Currently, the main treatments for
breast cancer are radiotherapy, chemotherapy, targeted therapy and surgery. The treatment …

Lung cancer is one of the most common cancers worldwide and the leading cause of death.
Early screening of lung cancer is exceptionally essential for later treatment. Abnormal lung …

Background Targeting tumor microenvironment (TME) may provide therapeutic activity and
selectivity in treating cancers. Therefore, an improved understanding of the mechanism by …

Dysregulation of the epigenetic processes, such as DNA methylation, histone modifications,
and modulation of chromatin states, drives aberrant transcription that promotes initiation and …

The incidence and mortality of lung cancer rank top three of all cancers worldwide.
Accounting for 85% of the total number of lung cancer, non-small cell lung cancer (NSCLC) …

Background Histone deacetylases (HDAC) contribute to oncogenic program, pointing to
their inhibitors as a potential strategy against cancers. We, thus, studied the mechanism of …

Mass spectrometry-based proteomics is a key player in research efforts to characterize
aberrant epigenetic alterations, including histone post-translational modifications and DNA …

Colorectal cancer (CRC) is one of the deadliest malignancies worldwide, ranking third in
incidence and second in mortality. Remarkably, early stage localized CRC has a 5-year …