Diabetic foot ulcers (DFU) are one of the most challenging complications of diabetes. Up to
one-third of patients with diabetes mellitus (DM) may suffer from DFUs during their life. DFU …

Diabetic foot ulcers (DFUs) are one of the most serious complications of diabetes mellitus
(DM). Although research has improved understanding of DFU etiology, an effective clinical …

Along with hypoxia, severe bacterial infection, and abnormal pH, continuous inflammatory
response hinders diabetic wounds from healing. It leads to the accumulation of large …

There is a high mortality in patients with diabetes and severe pressure ulcers. For example,
chronic pressure sores of the heels often lead to limb loss in diabetic patients. A major factor …

Diabetic nonhealing ulcers are the leading cause of nontraumatic amputations. An
increased cancer risk has been found in patients treated with current therapies such as …

Laser Doppler flowmetry (LDF) has long been considered a gold standard for non-invasive
assessment of skin microvascular function. Due to the laser Doppler (LD) microcirculatory …

Pressure ulcers are a significant healthcare problem affecting the quality of life in wheelchair
bounded or bed-ridden people and are a major cost to the healthcare system. Various …

Microvascular dysfunction in diabetes plays a crucial role in the development of diabetic
complications. The skin, as one of the most accessible organs, serves as a model for the …

According to the International Diabetes Federation, the challenge of early stage diagnosis
and treatment effectiveness monitoring in diabetes is currently one of the highest priorities in …

Nonhealing chronic wounds on foot induced by diabetes is a complicated pathologic
process. They are mainly caused by impaired neovascularization, neuropathy, and …