Evolutionary consequences of drug resistance: shared principles across diverse targets and organisms
D Hughes, DI Andersson - Nature Reviews Genetics, 2015 - nature.com
Drug therapy has a crucial role in the treatment of viral, bacterial, fungal and protozoan
infections, as well as the control of human cancer. The success of therapy is being …
infections, as well as the control of human cancer. The success of therapy is being …
A comprehensive survey of the mutagenic impact of common cancer cytotoxics
B Szikriszt, Á Póti, O Pipek, M Krzystanek, N Kanu… - Genome biology, 2016 - Springer
Background Genomic mutations caused by cytotoxic agents used in cancer chemotherapy
may cause secondary malignancies as well as contribute to the evolution of treatment …
may cause secondary malignancies as well as contribute to the evolution of treatment …
Kinetics and fidelity of the repair of Cas9-induced double-strand DNA breaks
EK Brinkman, T Chen, M de Haas, HA Holland… - Molecular cell, 2018 - cell.com
The RNA-guided DNA endonuclease Cas9 is a powerful tool for genome editing. Little is
known about the kinetics and fidelity of the double-strand break (DSB) repair process that …
known about the kinetics and fidelity of the double-strand break (DSB) repair process that …
Polyploidy can drive rapid adaptation in yeast
Polyploidy is observed across the tree of life, yet its influence on evolution remains
incompletely understood,,,. Polyploidy, usually whole-genome duplication, is proposed to …
incompletely understood,,,. Polyploidy, usually whole-genome duplication, is proposed to …
Quantitative evolutionary dynamics using high-resolution lineage tracking
Evolution of large asexual cell populations underlies∼ 30% of deaths worldwide, including
those caused by bacteria, fungi, parasites, and cancer. However, the dynamics underlying …
those caused by bacteria, fungi, parasites, and cancer. However, the dynamics underlying …
Epigenetic modifications affect the rate of spontaneous mutations in a pathogenic fungus
Mutations are the source of genetic variation and the substrate for evolution. Genome-wide
mutation rates appear to be affected by selection and are probably adaptive. Mutation rates …
mutation rates appear to be affected by selection and are probably adaptive. Mutation rates …
A hydrophobic ratchet entrenches molecular complexes
Most proteins assemble into multisubunit complexes. The persistence of these complexes
across evolutionary time is usually explained as the result of natural selection for functional …
across evolutionary time is usually explained as the result of natural selection for functional …
Adaptation of S. cerevisiae to Fermented Food Environments Reveals Remarkable Genome Plasticity and the Footprints of Domestication
The budding yeast Saccharomyces cerevisiae can be found in the wild and is also
frequently associated with human activities. Despite recent insights into the phylogeny of this …
frequently associated with human activities. Despite recent insights into the phylogeny of this …
Mutualism-enhancing mutations dominate early adaptation in a two-species microbial community
Species interactions drive evolution while evolution shapes these interactions. The resulting
eco-evolutionary dynamics and their repeatability depend on how adaptive mutations …
eco-evolutionary dynamics and their repeatability depend on how adaptive mutations …
Transposition favors the generation of large effect mutations that may facilitate rapid adaption
L Quadrana, M Etcheverry, A Gilly, E Caillieux… - Nature …, 2019 - nature.com
Transposable elements (TEs) are mobile parasitic sequences that have been repeatedly
coopted during evolution to generate new functions and rewire gene regulatory networks …
coopted during evolution to generate new functions and rewire gene regulatory networks …