β-Carboline alkaloid monomers and dimers: Occurrence, structural diversity, and biological activities

J Dai, W Dan, U Schneider, J Wang - European Journal of Medicinal …, 2018 - Elsevier
Abstract β-Carboline alkaloids are a family of natural and synthetic products with great
structural diversity and outstanding biological activities. This review covers critically …

Recent update on anti-dengue drug discovery

SN Dighe, K Dua, DK Chellappan, PL Katavic… - European journal of …, 2019 - Elsevier
Dengue is the most important arthropod-borne viral disease of humans, with more than half
of the global population living in at-risk areas. Despite the negative impact on public health …

Synthesis of β-Carboline-Based N-Heterocyclic Carbenes and Their Antiproliferative and Antimetastatic Activities against Human Breast Cancer Cells

SU Dighe, S Khan, I Soni, P Jain, S Shukla… - Journal of Medicinal …, 2015 - ACS Publications
A series of novel β-carboline-based N-heterocyclic carbenes was prepared via Mannich
reaction between methyl 1-(dimethoxymethyl)-9 H-pyrido [3, 4-b] indole-3-carboxylate …

Antiviral activity of natural and synthetic β-carbolines against dengue virus

VM Quintana, LE Piccini, JDP Zénere, EB Damonte… - Antiviral research, 2016 - Elsevier
Dengue virus (DENV) is the most prevalent mosquito borne viral pathogen worldwide. In this
work we first evaluated the antiviral activity of natural and synthetic β-carbolines against …

Novel Canthin-6-One Derivatives: Design, Synthesis, and Their Antiproliferative Activities Via Inducing Apoptosis, Deoxyribonucleic Acid Damage, and Ferroptosis

J Ding, T Sun, H Wu, H Zheng, S Wang, D Wang… - ACS …, 2023 - ACS Publications
A series of novel canthin-6-one (CO) derivatives (8a–l) were designed and synthesized by
introducing different amide side chains at the C-2 position, and their water solubility …

1 (3)‐Formyl‐β‐carbolines: Potential Aldo‐X Precursors for the Synthesis of β‐Carboline‐Based Molecular Architectures

N Devi, S Kumar, SK Pandey… - Asian Journal of Organic …, 2018 - Wiley Online Library
Abstract β‐Carboline, a privileged scaffold in the alkaloid family, has a broad spectrum of
medicinal properties and is found in several commercial drugs, such as tadalafil …

Harmine, a small molecule derived from natural sources, inhibits enterovirus 71 replication by targeting NF-κB pathway

D Chen, X Tian, X Zou, S Xu, H Wang, N Zheng… - International …, 2018 - Elsevier
Abstract Enterovirus 71 (EV71) infection of young children can cause neurological
manifestations, which is mainly responsible for the fatality. Although a vaccine is recently …

Synthesis and evaluation of novel hybrids β-carboline-4-thiazolidinones as potential antitumor and antiviral agents

VA Barbosa, P Baréa, RS Mazia… - European journal of …, 2016 - Elsevier
A series of novel hybrids β-carboline-4-thiazolidinones were synthesized and evaluated for
their in vitro antitumor activity against human cancer cell lines and for antiviral activity …

Microwave‐Assisted Synthesis of Tetrahydro‐β‐carbolines and β‐Carbolines

S Eagon, MO Anderson - European Journal of Organic …, 2014 - Wiley Online Library
A microwave‐mediated Pictet–Spengler procedure utilizing 1, 2‐dichloroethane (DCE) and
trifluoroacetic acid (TFA) was developed to provide tetrahydro‐β‐carboline salts in high …

Synthesis, antileishmanial and antitrypanosomal activities of N-substituted tetrahydro-β-carbolines

S Manda, SI Khan, SK Jain, S Mohammed… - Bioorganic & medicinal …, 2014 - Elsevier
A series of N-substituted tetrahydro-β-carbolines were synthesized and screened for
antileishmanial activity through an in vitro assay that involves promastigotes and axenic …