Updates and advances in multiple sclerosis neurotherapeutics

M Amin, CM Hersh - Neurodegenerative disease management, 2023 - Taylor & Francis
The multiple sclerosis (MS) neurotherapeutic landscape is rapidly evolving. New disease-
modifying therapies (DMTs) with improved efficacy and safety, in addition to an expanding …

Leveraging real-world evidence and observational studies in treating multiple sclerosis

A Aboseif, I Roos, S Krieger, T Kalincik… - Neurologic …, 2024 - neurologic.theclinics.com
In a rapidly evolving treatment landscape for multiple sclerosis (MS), the utilization of real-
world observational studies has become increasingly valuable for decisionmaking at the …

The Parkinson's disease waiting room of the future: measurements, not magazines

JL Alberts, U Shuaib, H Fernandez, BL Walter… - Frontiers in …, 2023 - frontiersin.org
Utilizing technology to precisely quantify Parkinson's disease motor symptoms has evolved
over the past 50 years from single point in time assessments using traditional biomechanical …

Improvements in cognitive processing speed, disability, and patient-reported outcomes in patients with early relapsing-remitting multiple sclerosis treated with …

J Perumal, R Balabanov, R Su, R Chang, LJ Balcer… - CNS drugs, 2022 - Springer
Background STRIVE was a prospective, 4-year, multicenter, observational, open-label,
single-arm study of natalizumab treatment in anti-JC virus antibody-negative patients with …

[HTML][HTML] Exploratory clinical efficacy and patient-reported outcomes from NOVA: A randomized controlled study of intravenous natalizumab 6-week dosing versus …

LZ Ryerson, JF Foley, G Defer, JA Cohen… - Multiple Sclerosis and …, 2023 - Elsevier
Abstract Background Natalizumab (TYSABRI®) 300 mg administered intravenously every-4-
weeks (Q4W) is approved for treatment of relapsing-remitting multiple sclerosis but is …

Characterizing the 'feel-good experience'in multiple sclerosis patients treated with natalizumab or other therapies

J Foley, R Berkovich, M Gudesblatt, E Luce… - Neurodegenerative …, 2023 - Taylor & Francis
Aim: Patients with relapsing–remitting multiple sclerosis (RRMS) treated with natalizumab
have anecdotally reported a 'feel-good experience'(FGE). The authors characterized the …

Sleep counts! Role and impact of sleep in the multimodal management of multiple sclerosis

MP Mogavero, G Lanza, O Bruni, LM DelRosso… - Journal of …, 2023 - Springer
Background In the last years, research on pharmacotherapy and non-pharmacological
approaches to Multiple Sclerosis (MS) has significantly increased, along with a greater …

Comparison of time to clinically meaningful improvement in quality of life in neurological disorders in patients treated with natalizumab versus ocrelizumab

CM Hersh, M Pang, DM Miller… - Neurodegenerative …, 2024 - Taylor & Francis
Aim: To assess time to improvement in Quality of Life in Neurological Disorders (Neuro-QoL)
domains for patients treated with natalizumab versus ocrelizumab. Methods: Patients …

Real-world evidence and patient preference for subcutaneous versus intravenous natalizumab in the treatment of relapsing-remitting multiple sclerosis – initial results …

R Gold, S Schmidt, F Deisenhammer… - Therapeutic …, 2024 - journals.sagepub.com
Background: The consideration of patient preference for a certain drug route of
administration (RoA) plays an important role in promoting patient adherence in chronic …

[HTML][HTML] Correlation of disability with quality of life in patients with multiple sclerosis treated with natalizumab: Primary results and post hoc analysis of the TYSabri …

L Achtnichts, C Zecca, O Findling, CP Kamm… - BMJ neurology …, 2023 - ncbi.nlm.nih.gov
Background In patients with multiple sclerosis (MS), relapses and disability progression
have been associated with decreased health-related quality of life (HRQoL). Methods …