The gut microbiota has been linked to the development of obesity and type 2 diabetes (T2D).
The underlying mechanisms as to how intestinal microbiota may contribute to T2D are only …

Low-grade tissue inflammation induced by obesity can result in insulin resistance, which in
turn is a key cause of type 2 diabetes mellitus. Cells of the innate immune system produce …

The innate immune system includes several classes of pattern recognition receptors (PRRs),
including membrane-bound Toll-like receptors (TLRs) and nucleotide-binding …

Type 2 diabetes mellitus (T2D) is a complex disease characterized by β-cell failure in the
setting of insulin resistance. The current evidence suggests that genetic predisposition, and …

When cells undergo necrotic cell death in either physiological or pathophysiological settings
in vivo, they release highly immunogenic intracellular molecules and organelles into the …

В монографии приведены сведения по роли цитокинов в регуляции физиологических
процессов, защитных реакций организма и в патогенезе иммунопатологических …

Toll-like receptors (TLRs) are a class of proteins that recognize pathogen-associated
molecular patterns (PAMPs) and damaged-associated molecular patterns (DAMPs), and …

This article is the second part of a review that addresses the role of damage-associated
molecular patterns (DAMPs) in human diseases by presenting examples of traumatic …

The NLRP3 inflammasome is a multiprotein complex that regulates the activation of caspase-
1 leading to the maturation of the proinflammatory cytokines IL-1β and IL-18 and promoting …

Type 2 diabetes has traditionally been viewed as a metabolic disorder characterised by
chronic high glucose levels, insulin resistance, and declining insulin secretion from the …