Ascidians (tunicates) are invertebrate chordates, and prolific producers of a wide variety of
biologically active secondary metabolites from cyclic peptides to aromatic alkaloids. Several …

This review examines the state of the art in synthesis as it relates to the building of complex
architectures on scales sufficient to drive human drug trials. We focus on the relatively few …

Non‐oxidative, regioselective, and convergent access to densely functionalized oxazoles is
realized in a functional‐group tolerant manner using alkynyl thioethers. Sulfur‐terminated …

Over the past several decades, macrocyclic compounds have emerged as increasingly
significant therapeutic candidates in drug discovery. Their pharmacological activity hinges …

We disclose a practical catalytic method for arming bioactive amide-based natural products
and other small-molecule drugs with various functional handles for the synthesis of drug …

An enantioselective cascade aerobic oxidation and semipinacol rearrangement reaction of 2‐
aryl‐3‐alkyl‐substituted indoles via visible‐light‐driven cooperative organophotoredox and …

The present volume is the third in a trilogy that documents naturally occurring
organohalogen compounds, bringing the total number—from fewer than 25 in 1968—to …

An efficient and novel method has been developed for the synthesis of indazole-containing
biheteroaryls via a domino Sonogashira coupling/azaenyne cycloisomerization/Barton …

The previous two surveys documented a combined total of 4714 naturally occurring
organohalogen compounds, both biogenic and abiotic [1, 2]. In the subsequent two …

The regiodivergent synthesis of 4‐and 5‐sulfenyl oxazoles from 1, 4, 2‐dioxazoles and
alkynyl thioethers has been achieved. Gold‐catalysed conditions are used to favour the …