Lactation is critical to infant short-term and long-term health and protects mothers from
breast cancer, ovarian cancer and type 2 diabetes mellitus. The mammary gland is a …

The mammary gland is a highly dynamic organ that undergoes profound changes within its
epithelium during puberty and the reproductive cycle. These changes are fueled by …

The breast is a dynamic organ whose response to physiological and pathophysiological
conditions alters its disease susceptibility, yet the specific effects of these clinical variables …

The development of the mammary gland is unique: the final stages of development occur
postnatally at puberty under the influence of hormonal cues. Furthermore, during the life of …

Characterising the hierarchy of mammary epithelial cells (MECs) and how they are
regulated during adult development is important for understanding how breast cancer …

Findings over the past decade have identified aberrant activation of the ETS transcription
factor family throughout all stages of tumorigenesis. Specifically in solid tumours, gene …

The mammary epithelium is highly responsive to local and systemic signals, which
orchestrate morphogenesis of the ductal tree during puberty and pregnancy. Based on …

The mammary epithelium undergoes profound morphogenetic changes during
development. Architecturally, it comprises two primary lineages, the inner luminal and outer …

Breast cancers in BRCA1 mutation carriers frequently have a distinctive basal-like
phenotype. It has been suggested that this results from an origin in basal breast epithelial …

Controversy surrounds reports describing the derivation of human trophoblast cells from
placentas and embryonic stem cells (ESC), partly due to the difficulty in identifying markers …