Strategies for unlocking immunosuppression in the tumor microenvironment have been
investigated to overcome resistance to first-generation immune checkpoint blockade with …

The environment, diet, microbiota and body's metabolism shape complex biological
processes in health and disease. However, our understanding of the molecular pathways …

Inhibited immune response and low levels of delivery restrict starvation cancer therapy
efficacy. Here, we report on the co-delivery of glucose oxidase (GOx) and indoleamine 2, 3 …

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that is
activated by small molecules provided by the diet, microorganisms, metabolism, and …

Despite the enormous therapeutic potential of immune checkpoint blockade (ICB), it benefits
only a small subset of patients. Some chemotherapeutics can switch 'immune-cold'tumours …

Indoleamine 2, 3-dioxygenase (IDO) has immunoregulatory roles associated with tryptophan
metabolism. These include counter-regulation (controlling inflammation) and acquired …

Inflammatory cytokines are commonly elevated in acute depression and are associated with
resistance to monoaminergic treatment. To examine the potential role of cytokines in the …

Breast cancer (BC) is one of the most common causes of cancer in the world and the second
leading cause of cancer deaths among women. Mortality is associated mainly with the …

While chemotherapy delivery by nanocarriers has modestly improved the survival prospects
of pancreatic ductal adenocarcinoma (PDAC), additional engagement of the immune …

Acetate is a major nutrient that supports acetyl-coenzyme A (Ac-CoA) metabolism and thus
lipogenesis and protein acetylation. However, its source is unclear. Here, we report that …